Organic Chemistry: 100 Must-Know Mechanisms

Description

In chemistry, good problem-solving requires a balanced combination of scientific intuition and methodical analysis. Additionally, thoughtfully presented diagrams and infographics can convey a large amount of complex information in a more intuitive and accessible manner. 100 Must-Know Mechanisms (Second Edition) strives to be at the intersection of these two key principles. Its thorough visualizations enable experienced readers to use it as a quick reference for specific mechanisms of interest. At the same time, the book’s breadth of covered reactions, from classic to cutting-edge, make it a good study-aid for the developing chemist. A slow and consistent study of the entire series of mechanisms can help set the foundation for good scientific intuition, while its detailed infographics and careful navigation features encourage coming back to it frequently. This edition includes over 40 new illustrations, numerous new mechanistic schemes, enhanced original figures with a variety of real-case examples, and more New in this edition: Dot structure added for most mechanisms. Selected mechanisms accompanied by specific examples with step-by-step explanation using Lewis dot structures. Name reactions accompanied by additional detailed mechanisms. Second Edition Preface and Overview Contents List of Acronyms and Abbreviations 1 Electrophilic Addition Mechanism 2 Nucleophilic Substitution Mechanism 3 Aromatic Electrophilic Substitution Mechanism  4 Aromatic Nucleophilic Substitution Mechanism 5 Aromatic Radical Nucleophilic Substitution Mechanism 6 Elimination Mechanism 7 Acyloin Condensation 8 Alkyne Zipper Reaction 9 Arbuzov Reaction 10 Arndt–Eistert Synthesis 11 Baeyer–Villiger Oxidation 12 Barton Decarboxylation 13 Baylis–Hillman Reaction 14 Beckmann Rearrangement 15 Benzoin Condensation 16 Benzyne Mechanism 17 Bergman Cyclization 18 Birch Reduction 19 Bischler‒Napieralski Cyclization 20 Brown Hydroboration 21 Buchwald–Hartwig Cross-Coupling 22 Cannizzaro Reaction 23 Chan–Evans–Lam Cross-Coupling 24 Chichibabin Amination 25 Claisen Condensation 26 Claisen Rearrangement 27 Cope Elimination 28 Cope Rearrangement 29 Criegee and Malaprade Oxidation 30 CuAAC 31 Curtius Rearrangement 32 Darzens Condensation 33 Dess–Martin Oxidation 34 Diazotization (Diazonium Salt) 35 Diels–Alder Cycloaddition 36 Di-π-Methane Rearrangement 37 Favorskii Rearrangement 38 Fischer Indole Synthesis 39 Friedel–Crafts Acylation and Alkylation 40 Gabriel Synthesis 41 Gewald Reaction 42 Glaser–Eglinton–Hay Coupling 43 Grignard Reaction 44 Grob Fragmentation 45 Haloform Reaction 46 Heck Cross-Coupling 47 Hell–Volhard–Zelinsky Reaction 48 Hiyama Cross-Coupling 49 Hofmann Elimination 50 Horner–Wadsworth–Emmons Olefination 51 Jones Oxidation 52 Kucherov Reaction 53 Kumada Cross-Coupling 54 Ley–Griffith Oxidation 55 Liebeskind–Srogl Cross-Coupling 56 Mannich Reaction 57 McMurry Coupling Fig. 58 Meerwein–Ponndorf–Verley Reduction 59 Michael Addition 60 Minisci Reaction 61 Mitsunobu Reaction 62 Miyaura Borylation 63 Mukaiyama RedOx Hydration 64 Nazarov Cyclization 65 Nef Reaction 66 Negishi Cross-Coupling 67 Norrish Type I and II Reactions 68 Olefin (Alkene) Metathesis 69 Oppenauer Oxidation 70 Ozonolysis 71 Paal–Knorr Syntheses 72 Paternò–Büchi Reaction 73 Pauson–Khand Reaction 74 Peptide (Amide) Coupling 75 Pictet–Spengler Reaction 76 Pinacol–Pinacolone Rearrangement 77 Polonovski Reaction 78 Prilezhaev Epoxidation 79 Prins Reaction 80 Pummerer Rearrangement 81 Ramberg–Bäcklund Rearrangement 82 Reformatsky Reaction 83 Robinson Annulation 84 Shapiro Reaction 85 Sonogashira Cross-Coupling 86 Staudinger Reaction 87 Steglich Esterification 88 Stille Cross-Coupling 89 Suzuki Cross-Coupling 90 Swern Oxidation 91 Ugi Reaction 92 Ullmann Aryl–Aryl Coupling 93 Upjohn Dihydroxylation 94 Vilsmeier–Haack Reaction 95 Wacker Oxidation 96 Wagner–Meerwein Rearrangement Fi 97 Weinreb Ketone Synthesis 98 Wittig Reaction 99 Wohl–Ziegler Reaction 100 Wolff–Kishner Reduction Acknowledgments Bibliography and References