Shargel and Yu's Applied Biopharmaceutics & Pharmacokinetics, 8th Edition

Description

The authoritative textbook on the principles and practical applications of biopharmaceutics and pharmacokinetics Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics has been the standard textbook in its field for over 40 years.  This eighth edition includes recent scientific developments in the field and embodies the collective contribution of experts with deep knowledge and experience in the selected subject areas.  Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition provides the reader with a fundamental understanding of biopharmaceutics and pharmacokinetics principles that can be applied to patient drug therapy and rational drug product development. Shargel & Yu's Applied Biopharmaceutics & Pharmacokinetics, Eighth Edition has been expanded and revised to include advancements in biopharmaceutics and pharmacokinetics. The chapter sequence has been reorganized into four main sections, providing a more logical sequence for students. The textbook starts with fundamental concepts, followed by application of these principles to optimize drug therapy and to the rational development of drug products. Each chapter includes theoretical concepts with practical examples and clinical applications. Frequently asked questions provide a discussion of overall concepts. Features: Expanded and revised chapters to include scientific advances in biopharmaceutics and pharmacokineticsFour main sections providing a natural buildup of knowledge: introduction to biopharmaceutics and pharmacokinetics, fundamentals of biopharmaceutics, pharmacokinetic calculations, clinical pharmacokinetics and pharmacodynamics, and biopharmaceutics and pharmacokinetics in drug product developmentAdditional chapters for this edition include:   oPhysiological factors related to drug absorption oApproaches to pharmacokinetics and pharmacodynamics calculations  oNovel and complex dosage Forms oClinical Development and Therapeutic Equivalence of Generic Drug and Biosimilar Products oPharmacokinetics and Pharmacodynamics in Clinical Drug Product Development Additional information on drug therapy, drug product performance, and other related topicsFrequently asked questions, practice problems, clinical examples and learning questions Chapter 1_ Introduction to Biopharmaceutics and Pharmacokinetics Chapter 2_ Mathematical Fundamentals in Pharmacokinetics Chapter 3_ Biostatistics Chapter 4_ Physiologic Factors Related to Drug Absorption Chapter 5_ Drug Distribution and Protein Binding Chapter 6_ Physiology of Drug Elimination Chapter 7_ Biopharmaceutic Considerations in Drug Product Design and In Vitro Drug Product Performance Chapter 8_ Drug Product Performance, In Vivo_ Bioavailability and Bioequivalence Chapter 9_ Modified-Release Drug Products and Drug Devices Chapter 10_ Targeted Drug Delivery Systems and Biotechnology Products Chapter 11_ Introduction to Pharmacokinetic and Pharmacodynamic Models and Analyses Chapter 12_ One-Compartment Open Model_ Intravenous Bolus Administration Chapter 13_ Multicompartment Models_ Intravenous Bolus Administration Chapter 14_ Intravenous Infusion Chapter 15_ Pharmacokinetic Calculations for Drug Elimination and Clearance Chapter 16_ Pharmacokinetics of Drug Absorption Chapter 17_ Multiple-Dosage Regimens Chapter 18_ Nonlinear Pharmacokinetics Chapter 19_ Empirical Models, Mechanistic Models, Statistical Moments, and Noncompartmental PK_PD Analyses Chapter 20_ Applications of Software Packages in Pharmacokinetics Chapter 21_ Pharmacogenetics, Drug Metabolism, Transporters, and Individualization of Drug Therapy Chapter 22_ Relationship between Pharmacokinetics and Pharmacodynamics Chapter 23_ Application of Pharmacokinetics to Clinical Situations Chapter 24_ Application of Pharmacokinetics and Pharmacodynamics to Aging, Obese, and Pediatric Patients Chapter 25_ Dose Adjustment in Renal and Hepatic Diseases Chapter 26_ Biopharmaceutical Aspects of the Active Pharmaceutical Ingredient and Pharmaceutical Equivalence Chapter 27_ Rational Drug Product Development, Quality, and Performance Chapter 28_ FDA-Approved Novel Dosage Forms Chapter 29_ Clinical Development and Therapeutic Equivalence of Generic Drugs and Biosimilar Products Chapter 30_ Pharmacokinetics and Pharmacodynamics in Clinical Drug Product Development Glossary