ENGLISH

Statistical Monitoring of Clinical Trials: A Unified Approach (Statistics for Biology and Health)

By Michael A. Proschan , Janet Turk Wittes , K. K. Gordon Lan

Book information

Publisher
Springer
Year
2006
ISBN
0387300597, 9780387300597
LCC
R853.C55 .P76 2006
Google Books ID
BCu8c8NwXxcC
Open Library ID
OL7445226M
Language
english
Format
PDF
Filesize
3 MB (3331664 bytes)
Series
Statistics for biology and health
Pages
271\271
Orientation
yes
Scanned
no
Time added
2012-02-14 18:00:00

Description

The approach taken in this book is, to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ("the B-value") – irrespective of the test statistic. Thus, this book offers statisticians an accessible, incremental approach to understanding Brownian motion as related to clinical trials.

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