Immunotherapy in Transplantation: Principles and Practice
Book information
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This comprehensive reference source will benefit all transplant specialists working with pharmacologic and biologic agents that modulate the immune system. Compiled by a team of world-renowned editors and contributors covering the fields of transplantation, nephrology, pharmacology, and immunology, the book covers all anti-rejection drugs according to a set template and includes the efficacy of each for specific diseases.Content: Chapter 1 The Immune Response to a Transplanted Organ: An Overview (pages 3–9): Fadi G. LakkisChapter 2 Antigen Presentation in Transplantation (pages 10–18): Martin H. Oberbarnscheidt and Fadi G. LakkisChapter 3 The T Cell Response to Transplantation Antigens (pages 19–37): Didier A. Mandelbrot, Bryna Burrell, Mohamed H. Sayegh and Peter S. HeegerChapter 4 The B Cell Response to Transplantation Antigens (pages 38–53): Roger Sciammas, Anita S. Chong and Robert B. ColvinChapter 5 The Innate Response to a Transplanted Organ (pages 54–61): Daniel R. Goldstein and Laurence A. TurkaChapter 6 Regulation of the Alloimmune Response (pages 62–78): Kathryn J. Wood and Terry B. StromChapter 7 Pharmacokinetics (pages 81–94): Venkateswaran C. Pillai and Raman VenkataramananChapter 8 Therapeutic Drug Monitoring for Immunosuppressive Agents (pages 95–113): Michael C. Milone and Leslie M. J. ShawChapter 9 Pharmacometrics: Concepts and Applications to Drug Development (pages 114–132): Mallika Lala and Jogarao V. S. GobburuChapter 10 Pharmacogenomics and Organ Transplantation (pages 133–145): Gilbert J. Burckart and Richard M. WatanabeChapter 11 Study Design/Process of Development: Clinical Studies (pages 146–159): Richard D. MamelokChapter 12 Corticosteroids (pages 163–170): Olivia R. Blume, Sarah E. Yost and Bruce KaplanChapter 13 Azathioprine (pages 171–181): Barry J. BrowneChapter 14 Pharmacokinetic and Pharmacodynamic Properties of Mycophenolate (pages 182–196): David Hager, Arjang Djamali and Bruce KaplanChapter 15 Cyclosporine: Molecular Action to Clinical Therapeutics (pages 197–223): Bradford Strijack and Paul A. KeownChapter 16 Tacrolimus (pages 224–240): William E. FitzsimmonsChapter 17 Inhibitors of Mammalian Target of Rapamycin (pages 241–272): Barry D. KahanChapter 18 Inhibitors Targeting JAK3 (pages 273–289): Gary Chan and Paul S. ChangelianChapter 19 Cyclophosphamide (pages 290–295): John J. CurtisChapter 20 Application of Antisense Technology in Medicine (pages 296–315): Beata Mierzejewska and Stanislaw M. StepkowskiChapter 21 The Role of Ganciclovir in Transplantation (pages 316–329): Lyndsey J. Bowman and Daniel C. BrennanChapter 22 Transplantation Immunotherapy with Antithymocyte Globulin (ATG) (pages 330–345): John L. Dzuris, Christian Bloy, Melanie Ruzek and John M. WilliamsChapter 23 The Role of Alemtuzumab in Solid Organ Transplantation (pages 346–361): Avinash Agarwal, David Bruno and Stuart J. KnechtleChapter 24 Rituximab, an Anti?CD20 Monoclonal Antibody (pages 362–377): Mark D. PescovitzChapter 25 The Anti?Interleukin 2 Receptor Antibodies (pages 378–384): Muna Alnimri and Flavio VincentiChapter 26 Infliximab/Anti?TNF (pages 385–398): Marina Vardanyan, Edward C. Parkin and Horacio L. Rodriguez RiloChapter 27 CTLA4?Ig (pages 399–406): Sarah E. Yost and Bruce KaplanChapter 28 Combination and Adjuvant Therapies to Facilitate the Efficacy of Costimulatory Blockade (pages 407–428): Swetha K. Srinivasan, Helen L. Triemer and Allan D. KirkChapter 29 Intravenous Immunoglobulin (IVIG) a Modulator of Immunity and Inflammation with Applications in Solid Organ Transplantation (pages 429–445): Stanley C. Jordan, Mieko Toyoda, Joseph Kahwaji, Alice Peng and Ashley A. Vo
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