New Concepts in Cancer: Metastasis, Oncogenes and Growth Factors

Description

Front Matter....Pages i-ix New Therapeutic Approaches in Recurrent Metastatic Disease....Pages 1-7 Features of Tumor Progression in H-ras transformed Rat Embryo Cells....Pages 8-21 Organ Specificity of Metastasis: Adhesive, Invasive and Growth Properties of Organ-Specific Metastatic Cells....Pages 22-41 Role of 12-Lipoxygenase Metabolites and Integrin Glycoprotein Receptors in Metastasis....Pages 42-62 The Rapid Destruction of Cancer Cells in the Microvasculature....Pages 63-73 The Control of Cell Movement by Laminin, and its Role in Metastasis....Pages 74-92 Dormant Metastatic Cells: Hypotheses on Mechanisms, Magnitude, Failure and Control....Pages 93-99 Estrogen-induced Pro-cathepsin D and its Relationship to Breast Cancer Invasion and Metastasis....Pages 100-110 Metastatic Process Does Not Select Cells for Metastatic Ability But Metastatic Cells Are Selected for by Drug Resistance. Implications for Tumor Progression....Pages 111-126 Calcium Channel Blockers and Cisplatin: Synergistic Antimetastatic Effects....Pages 127-147 Assays In Vitro and In Vivo for Invasion and Metastasis: Application to Drug Testing....Pages 148-165 The Structure and Function of Growth Factor Receptors and Their Subversion in Cancer....Pages 166-180 Cell Growth Signaling in Fibroblasts: the Role of G-Proteins....Pages 181-195 The Bombesin Receptor Complex and Cell Growth: Physiology and Pathology....Pages 196-207 Hormonal Effects on Gastrointestinal Cancer Growth....Pages 208-217 Regulation of Fibroblastic and Epithelial Cell Function by Transforming Growth Factors....Pages 218-230 Back Matter....Pages 231-236