Hematopathology: Genomic Mechanisms of Neoplastic Diseases

Description

Hematopathology: Genomic Mechanisms of Neoplastic Diseases will keep physicians abreast of the rapid and complex changes in genomic medicine, as exemplified by the molecular pathology of hematologic malignancies. This timely volume will update physicians on the complexities of genomic lesions, as well as offer an integrated framework encompassing molecular diagnosis, the new WHO classification of hematologic neoplasms with focus on molecular pathology, prognostic value of molecular tests, and molecular monitoring of response to gene-targeted therapy. As such, it will be of great value to hematologists, oncologists, pathologists, internal medicine and pediatric specialists, as well as bioscientific staff and laboratorians in private hospitals and academic institutions. Front Matter....Pages i-xii Molecular Techniques in Hematopathology....Pages 1-38 Classical and Molecular Cytogenetic Analysis of Hematolymphoid Disorders....Pages 39-78 Using Cytogenetic and Molecular Tests in Diagnostic Workups with the WHO Classification – 2008....Pages 79-102 Update on the Molecular Pathology of Precursor Lymphoid Leukemias....Pages 103-126 Molecular Pathology of Acute Myeloid Leukemias....Pages 127-155 Molecular Pathology of Mature B-Cell and T-Cell Lymphomas....Pages 157-214 Molecular Pathology of Myeloproliferative Neoplasms....Pages 215-253 Molecular Pathology of Chronic Lymphocytic Leukemia....Pages 255-291 Targeted Therapy in Hematologic Malignancies....Pages 293-323 Micro-RNAs in Hematologic Malignancies....Pages 325-340 Back Matter....Pages 341-358