ISE Genetics: From Genes to Genomes (ISE HED WCB CELL & MOLECULAR BIOLOGY)

Description

Genetics: From Genes to Genomes is a cutting-edge, introductory genetics text authored by an unparalleled author team, including Nobel Prize winner, Leland Hartwell. This edition continues to build upon the integration of Mendelian and molecular principles, providing students with the links between the early understanding of genetics and the new molecular discoveries that have changed the way the field of genetics is viewed. Cover Title Copyright Brief Contents Contents About the Authors Preface Acknowledgments Part I: Basic Principles: How Traits Are Transmitted Chapter 1 Mendel's Principles of Heredity 1.1 The Puzzle of Inheritance 1.2 Genetic Analysis According to Mendel 1.3 Mendelian Inheritance in Humans Chapter 2 Extensions to Mendel's Laws 2.1 Extensions to Mendel for Single-Gene Inheritance 2.2 Extensions to Mendel for Two-Gene Inheritance 2.3 Extensions to Mendel for Complex Trait Inheritance 2.4 A Comprehensive Example: Dog Coat Color Genes Chapter 3 Chromosomes and Inheritance 3.1 Chromosomes: The Carriers of Genes 3.2 Mitosis: Cell Division that Preserves Chromosome Number 3.3 Meiosis: Cell Divisions that Halve Chromosome Number Genetics and Society: Prenatal Genetic Diagnosis Chapter 4 Sex Chromosomes 4.1 Sex Chromosomes and Sex Determination 4.2 Gametogenesis 4.3 Sex Linkage 4.4 Sex-Linked and Sexually Dimorphic Traits in Humans 4.5 Human Intersexuality Fast Forward: Transgenic Mice Prove that SRY Is the Maleness Factor Fast Forward: Visualizing X-Chromosome Inactivation in Transgenic Mice Chapter 5 Linkage, Recombination, and Gene Mapping 5.1 Gene Linkage and Recombination 5.2 Recombination: A Result of Crossing-Over During Meiosis 5.3 Mapping: Locating Genes Along a Chromosome 5.4 The Chi-Square Test and Linkage Analysis 5.5 Tetrad Analysis in Fungi 5.6 Mitotic Recombination and Genetic Mosaics Fast Forward: Mapping the Crossovers thatGenerate the Chromosomes of Individual Human Sperm Fast Forward: Gene Mapping Has Led to Treatments for Cystic Fibrosis Tools of Genetics: The Chi-Square Test for Goodness of Fit Genetics and Society: Mitotic Recombination and Cancer Part II: What Genes Are and What They Do Chapter 6 DNA Structure, Replication, and Recombination 6.1 Experimental Evidence for DNA as the Genetic Material 6.2 The Watson and Crick Double Helix Model of DNA 6.3 Genetic Information in Nucleotide Sequence 6.4 DNA Replication 6.5 Homologous Recombination at the DNA Level 6.6 Site-Specific Recombination Chapter 7 Mutation 7.1 Mutations: Primary Tools of Genetic Analysis 7.2 Molecular Mechanisms that Alter DNA Sequence 7.3 DNA Repair Mechanisms Fast Forward: Trinucleotide Repeat Diseases Chapter 8 Using Mutations to Study Genes 8.1 What Mutations Tell Us About Gene Structure 8.2 What Mutations Tell Us About Gene Function 8.3 A Comprehensive Example: Mutations that Affect Vision Chapter 9 Gene Expression: The Flow ofInformation from DNA to RNA to Protein 9.1 The Genetic Code 9.2 Transcription: From DNA to RNA 9.3 Translation: From mRNA to Protein 9.4 Differences in Gene ExpressionBetween Prokaryotes and Eukaryotes 9.5 The Effects of Mutations on Gene Expression and Function Genetics and Society: HIV and Reverse Transcription Part III: Analysis of Genetic Information Chapter 10 Digital Analysis of DNA 10.1 Fragmenting DNA 10.2 Cloning DNA Fragments 10.3 Sequencing DNA 10.4 Sequencing Genomes Tools of Genetics: Serendipity in Science: The Discovery of Restriction Enzymes Chapter 11 Genome Annotation 11.1 Finding the Genes in Genomes 11.2 Genome Architecture and Evolution 11.3 Bioinformatics: Information Technology and Genomes 11.4 A Comprehensive Example: The Hemoglobin Genes Chapter 12 Analyzing Genomic Variation 12.1 Variation Among Genomes 12.2 Genotyping a Known Disease-Causing Mutation 12.3 Sampling DNA Variation in a Genome 12.4 Positional Cloning 12.5 The Era of Whole-Genome Sequencing Fast Forward: Genetic Genealogy Tools of Genetics: The Lod Score Statistic Part IV: How Genes Travel on Chromosomes Chapter 13 The Eukaryotic Chromosome 13.1 Chromosomal DNA and Proteins 13.2 Chromosome Structure and Compaction 13.3 Chromosomal Packaging and Gene Expression 13.4 Replication of Eukaryotic Chromosomes 13.5 Chromosome Segregation 13.6 Artificial Chromosomes Chapter 14 Chromosomal Rearrangements 14.1 Rearrangements of Chromosomal DNA 14.2 The Effects of Rearrangements 14.3 Transposable Genetic Elements 14.4 Genome Restructuring and Evolution Fast Forward: Programmed DNA Rearrangements and the Immune System Chapter 15 Ploidy 15.1 Aberrations in Chromosome Number: Aneuploidy 15.2 Variation in Number of Chromosome Sets: Euploidy 15.3 Whole-Genome Duplication as a Driver of Evolution Chapter 16 Bacterial Genetics 16.1 The Enormous Diversity of Bacteria 16.2 Bacterial Genomes 16.3 Bacteria as Experimental Organisms 16.4 Gene Transfer in Bacteria 16.5 Using Genetics to Study Bacterial Life 16.6 A Comprehensive Example: How N. gonorrhoeae Became Resistant to Penicillin Genetics and Society: The Human Microbiome Project Chapter 17 Organellar Inheritance 17.1 Mitochondria and Their Genomes 17.2 Chloroplasts and Their Genomes 17.3 The Relationship Between Organellar and Nuclear Genomes 17.4 Non-Mendelian Inheritance of Mitochondria and Chloroplasts 17.5 Mutant Mitochondria and Human Disease Fast Forward: Mitochondrial Eve Part V: How Genes Are Regulated Chapter 18 Gene Regulation in Prokaryotes 18.1 The Elements of Prokaryotic Gene Expression 18.2 Regulation of Transcription Initiation via DNA-Binding Proteins 18.3 RNA-Mediated Mechanisms of Gene Regulation 18.4 Discovering and Manipulating Bacterial Gene Regulatory Mechanisms 18.5 A Comprehensive Example: Control of Bioluminescence by Quorum Sensing Chapter 19 Gene Regulation in Eukaryotes 19.1 Overview of Eukaryotic Gene Regulation 19.2 Control of Transcription Initiation Through Enhancers 19.3 Regulation After Transcription 19.4 A Comprehensive Example: Sex Determination in Drosophila Tools of Genetics: The Gal4/UASG Binary Gene Expression System Chapter 20 Epigenetics 20.1 Genomic Imprinting 20.2 Inheritance of Programmed Gene Repression Through Cell Division 20.3 Transgenerational Epigenetic Inheritance 20.4 A Comprehensive Example: Epigenetic Inheritance in Mice Part VI: Using Genetics Chapter 21 Manipulating the Genomes of Eukaryotes 21.1 Creating Transgenic Organisms 21.2 Uses of Transgenic Organisms 21.3 Targeted Mutagenesis 21.4 Human Gene Therapy Tools of Genetics: Cloning by Somatic Cell Nuclear Transfer Tools of Genetics: How Bacteria Use CRISPR/Cas9 to Vaccinate Themselves Against Viruses Genetics and Society: Should We Alter Human Germ-Line Genomes? Chapter 22 Genetic Analysis of Development 22.1 Model Organisms: Prototypes for Developmental Genetics 22.2 Mutagenesis Screens 22.3 Determining Where and When Genes Act 22.4 Ordering Genes in a Pathway 22.5 A Comprehensive Example: Body Plan Development in Drosophila Chapter 23 The Genetics of Cancer 23.1 Characteristics of Cancer Cells 23.2 The Genetic Basis of Cancers 23.3 How Cell Division Is Normally Controlled 23.4 How Mutations Cause Cancer 23.5 Personalized Cancer Treatment Tools of Genetics: Analysis of Cell-Cycle Mutants in Yeast Part VII: Beyond the Individual Gene and Genome Chapter 24 Variation and Selection in Populations 24.1 The Hardy-Weinberg Law: Predicting Genetic Variation in "Ideal" Populations 24.2 What Causes Allele Frequencies to Change in Real Populations? 24.3 Ancestry and the Evolution of Modern Humans Chapter 25 Genetic Analysis of Complex Traits 25.1 Heritability: Genetic Versus Environmental Influences on Complex Traits 25.2 Mapping Quantitative Trait Loci (QTLs) Tools of Genetics: The Chi-Square Test for Independence Guidelines for Gene Nomenclature Brief Answer Section Glossary A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Index A B C D E F G H I J K L M N O P Q R S T U V W X Y Z