ENGLISH

Epigenetics Protocols

By Trygve O. Tollefsbol

Book information

Publisher
Humana Press
Year
2004
ISBN
9781588293367, 158829336X, 1592598285
Language
english
Format
PDF
Filesize
10 MB (10259747 bytes)
Series
Methods in Molecular Biology 287
Edition
1
Pages
316\316
Topic
Biology Genetics
Scanned
no
Time added
2010-02-18 13:16:04

Description

A collection of state-of-the-art methods for epigenetic analysis, including recent breakthrough techniques that have great potential in the rapidly expanding field of non-Mendelian genetics. The authors provide techniques for the analysis of chromatin remodeling, such as histone acetylation and methylation. In addition, methods in newly developed and especially promising areas of epigenetics, such as telomere position effects, quantitative epigenetics, and ADP ribosylation are covered. There is also an updated analysis of techniques involving DNA methylation and its role in the modification, as well as the maintenance, of chromatin structure. Of special interest are potentially revolutionary techniques. These include methods for determining changes in native chromatin, methods of microarray analysis applied to epigenetics, and methylation-sensitive single-strand conformation techniques. The methods are suitable not only for studying fundamental biological processes, but also for investigating possible therapeutic interventions and such diseases as cancer.

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