ENGLISH

Minimal Residual Disease In Hematologic Malignancies (Acta Haematologica 2004)

By Pia Raanani , Andreas Hochhaus

Book information

Publisher
Karger
Year
2004
ISBN
3805577737, 9783805577731
DOI
10.1159/000077553
Open Library ID
OL12931682M
Language
english
Format
PDF
Filesize
2 MB (1941495 bytes)
Edition
1
Pages
120\120
Topic
Medicine Diseases
Time added
2011-06-04 13:46:07

Description

Detection of minimal residual disease (MRD) is increasingly used in the management of leukemia patients. A wide variety of methods have been developed and include technologies designed to detect residual malignant cells beyond the sensitivity of conventional approaches such as morphology and banding cytogenetics in leukemia. The choice of the best method depends on the biology of the individual malignancy, i.e. on the determination of specific markers which are useful to differentiate between leukemic cells and normal hematopoiesis in leukemic patients. These markers include leukocyte differentiation antigens, fusion transcripts, transcripts overexpressed by mutated or nonmutated genes, rearranged genes, and individual markers like polymorphic repetitive DNA sequences. The major technologies for MRD detection, their advantages and disadvantages and their clinical applications are discussed in this special issue - from 'bench to bedside'.

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