Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders

Description

This comprehensive, up-to-date book is designed to make recent developments in neuroimmunology accessible to medical professionals in the field. The field of neuroimmunology is complex and rapidly evolving, especially with the current improvements in targeted biologic therapies. This resource concisely offers clear explanations of these scientific and clinical advancements. Divided into five parts, the book begins with an in-depth introduction to neuroimmunology and the principles of immunotherapy. Section two consists of eight chapters devoted to multiple sclerosis, including discussions on the clinical features of the disease as well as symptom management and diagnosis. Subsequent chapters then dive into other central nervous system inflammatory disorders such as neuromyelitis optica, autoimmune encephalopathies, and immunological aspects of cancer. Following this are two chapters that examine distinct aspects of autoimmune disorders of the peripheral nervous system. Finally, the book closes with a review on the neurologic manifestations, diagnostic approaches and treatments of the various systemic rheumatic diseases. Following its successful predecessor edition, Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders, Second Edition is positioned to be an invaluable asset to neurologists, residents and fellows, internists, and general practitioners who treat patients with neurologic disorders and other systemic autoimmune diseases. Front Matter ....Pages i-xiii Front Matter ....Pages 1-1 Introduction to Neuroimmunology (Patricia K. Coyle)....Pages 3-15 Principles of Immunotherapy (Jennifer Joscelyn, Javier Ochoa-Repáraz, Lloyd Kasper)....Pages 17-42 Front Matter ....Pages 43-43 Immunopathogenesis (Patricia K. Coyle)....Pages 45-69 Epidemiology and Genetics (Tina Roostaei, Philip L. De Jager)....Pages 71-87 Clinical Features, Symptom Management, and Diagnosis (Jacqueline F. Rosenthal, James M. Stankiewicz, Guy J. Buckle)....Pages 89-108 Magnetic Resonance Imaging and Analysis in Multiple Sclerosis (Dejan Jakimovski, Deepa P. Ramasamy, Robert Zivadinov)....Pages 109-136 Disease-Modifying Agents (Syed A. Rizvi)....Pages 137-157 Clinical Decision-Making in the Management of Multiple Sclerosis (Syed A. Rizvi, Joshua A. Stone, Saima T. Chaudhry, Nichola Haddad, Brian Wong, Jennifer O. Grimes)....Pages 159-177 Multiple Sclerosis in Children (Charles D. Tyshkov, Leigh Elkins Charvet, Lauren B. Krupp)....Pages 179-196 Vitamin D and Multiple Sclerosis (Michael J. Bradshaw, Michael F. Holick, James M. Stankiewicz)....Pages 197-212 Front Matter ....Pages 213-213 Acute Disseminated Encephalomyelitis (Patricia K. Coyle)....Pages 215-226 Neuromyelitis Optica Spectrum Disorders (Jonathan F. Cahill)....Pages 227-234 Paraneoplastic and Other Autoimmune Disorders (Alexander Mohler, Mayra Montalvo, Julie Roth)....Pages 235-255 Adult and Childhood Vasculitis of the Nervous System (David S. Younger)....Pages 257-281 Front Matter ....Pages 283-283 Immunologic Disorders of Neuromuscular Junction and Muscle (James M. Gilchrist, John E. Donahue)....Pages 285-298 Autoimmune Neuropathies (Jacques Reynolds, George Sachs)....Pages 299-317 Front Matter ....Pages 319-319 Neurologic Manifestations of Systemic Rheumatologic Diseases (Michael J. Bradshaw, Shamik Bhattacharyya, Nagagopal Venna, Jonathan F. Cahill)....Pages 321-342 Back Matter ....Pages 343-353