ENGLISH

Pharmacology of Immunotherapeutic Drugs

By Clinton B. Mathias , Jeremy P. McAleer , Doreen E. Szollosi

Book information

Publisher
Springer International Publishing
Year
2020
ISBN
978-3-030-19921-0, 978-3-030-19922-7
Language
english
Format
PDF
Filesize
12 MB (12318679 bytes)
Edition
1st ed. 2020
Pages
XIX, 399\410
Time added
2020-02-08 04:41:09
Biomedicine; Pharmacology/Toxicology; Immunology

Description

Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are detailed. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.​ Front Matter ....Pages i-xix Overview of the Immune System and Its Pharmacological Targets (Clinton B. Mathias)....Pages 1-42 Modulation of the Innate Immune System (Doreen E. Szollosi, Clinton B. Mathias)....Pages 43-66 Modulation of the Adaptive Immune System (Doreen E. Szollosi, Clinton B. Mathias, Jeremy P. McAleer)....Pages 67-98 Respiratory Disorders of the Immune System and Their Pharmacological Treatment (Clinton B. Mathias)....Pages 99-140 Inflammation of the Skin and Its Therapeutic Targets (Clinton B. Mathias)....Pages 141-174 Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological Treatments (Clinton B. Mathias, Jeremy P. McAleer, Doreen E. Szollosi)....Pages 175-205 Mechanisms of Autoimmunity and Pharmacologic Treatments (Doreen E. Szollosi, Kirsten Hokeness, Mohammed K. Manzoor)....Pages 207-249 Transplantation: Immunologic Principles and Pharmacologic Agents (Clinton B. Mathias, Jeremy P. McAleer)....Pages 251-276 Immunopathogenesis, Immunization, and Treatment of Infectious Diseases (Doreen E. Szollosi, Clinton B. Mathias, Victoria Lucero, Sunna Ahmad, Jennifer Donato)....Pages 277-319 Cancer Immunotherapy (Doreen E. Szollosi, Shannon R. M. Kinney, A. R. M. Ruhul Amin, Ngumbah Chumbow)....Pages 321-355 Back Matter ....Pages 357-399

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