Neural Regulation of Metabolism

Description

This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism. Front Matter ....Pages i-xi Functional Interrogation of the AgRP Neural Circuits in Control of Appetite, Body Weight, and Behaviors (Yong Han, Guobin Xia, Qi Wu)....Pages 1-16 POMC Neurons: Feeding, Energy Metabolism, and Beyond (Cheng Zhan)....Pages 17-29 Neuronal cAMP/PKA Signaling and Energy Homeostasis (Linghai Yang)....Pages 31-48 Synaptic Regulation of Metabolism (Jie Xu, Christopher L. Bartolome, Dong Kong)....Pages 49-77 Central Circadian Clock Regulates Energy Metabolism (Guolian Ding, Yingyun Gong, Kristin L. Eckel-Mahan, Zheng Sun)....Pages 79-103 Glial Regulation of Energy Metabolism (Yu-Dong Zhou)....Pages 105-121 The Leptin Signaling (Jiarui Liu, Xiaoning Yang, Siwang Yu, Ruimao Zheng)....Pages 123-144 The Leptin Resistance (Jiarui Liu, Xiaoning Yang, Siwang Yu, Ruimao Zheng)....Pages 145-163 Ghrelin Signaling in Immunometabolism and Inflamm-Aging (Chuo Fang, Hang Xu, Shaodong Guo, Susanne U. Mertens-Talcott, Yuxiang Sun)....Pages 165-182 Electrophysiological Mechanism of Peripheral Hormones and Nutrients Regulating Energy Homeostasis (Zhuo Huang, Kuo Xiao)....Pages 183-198 Regulation of Lipolysis in Adipose Tissue and Clinical Significance (Xin Li, Kai Sun)....Pages 199-210 Current Genetic Techniques in Neural Circuit Control of Feeding and Energy Metabolism (Qi Wu, Yong Han, Qingchun Tong)....Pages 211-233