Integrin Targeting Systems for Tumor Diagnosis and Therapy

Description

This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory. Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research. Front Matter ....Pages i-xi Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnetic Iron Oxides (Fabienne Danhier, Pierre Danhier, Nathalie Schleich, Chrystelle Po, Sophie Laurent, Pierre Sibret et al.)....Pages 1-17 Fabrication of cRGD-Conjugated Dual-Responsive Micelles to Target αvβ5 Integrin-Overexpressed Cancer (Huacheng He, Remant Bahadur K.C., Peisheng Xu)....Pages 19-34 Copper-Free Click Chemistry Modification of Nanovectors for Integrin-Targeted Cancer Therapy (Chang-Fang Wang, Hélder A. Santos)....Pages 35-49 Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal Doxorubicin Modified with Different cRGD Peptides (Mohamadreza Amin, Mahmoud Reza Jaafari)....Pages 51-68 Preparation of Heterobivalent and Multivalent Radiopharmaceuticals to Target Tumors Over-Expressing Integrins (Guillermina Ferro-Flores, Blanca Ocampo-García, Clara Santos-Cuevas, Nallely Jiménez-Mancilla, Myrna Luna-Gutiérrez, Flor de M. Ramírez et al.)....Pages 69-92 177Lu-Labeled RGD-BBN Peptide for Targeting Prostate Cancer (Lei Jiang, Zhen Cheng)....Pages 93-98 Integrin-Mediated Targeting of Liposomally Bound siRNAs to Tumor Vasculatures (Poulami Majumder, Arabinda Chaudhuri)....Pages 99-122 Integrin αvβ3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide (Hao Hong, Weibo Cai)....Pages 123-134 Integrin Targeting Using RGD-Based Peptide Amphiphiles (Poonam Saraf, Xiaoling Li, Bhaskara Jasti)....Pages 135-155 Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting (Hitesh Kulhari, Deep Pooja, Shweta Shrivastava, T. Srinivasa Reddy, Ayan Kumar Barui, Chitta Ranjan Patra et al.)....Pages 157-168 Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds via Integrin Receptors (Jitka Neburkova, Miroslav Hajek, Ivan Rehor, Jiri Schimer, Frantisek Sedlak, Jan Stursa et al.)....Pages 169-189 NIR Imaging-Guided Photothermal Therapy by cRGD-Conjugated Solid Lipid Nanoparticles Encapsulating IR-780 (Ye Kuang, Kunchi Zhang, Min Liu, Renjun Pei)....Pages 191-206 Synergistic Active Targeting to B16F10 Tumors by αvβ3/CD44-Targeted Nanoparticles Loaded with Docetaxel (Sanjun Shi)....Pages 207-223 Back Matter ....Pages 225-226