ENGLISH

CX3CR1

By Imai T. , Yoshie O.

Book information

DOI
10.1006/rwcy.2000.22016
Language
english
Format
PDF
Filesize
70 kB (71366 bytes)
Pages
6\6
Library
mexmat
Time added
2009-07-20 03:45:11

Description

CX3CR1 is a specific receptor for fractalkine/neurotactin (CX3CL1), a transmembrane molecule having an N-terminal chemokine domain with the CX3C motif. Membrane-bound fractalkine induces a rapid integrin-independent firm adhesion of leukocytes expressing CX3CR1 without involving any other adhesion molecules or G protein signaling; while soluble fractalkine induces vigorous chemotaxis of leukocytes expressing CX3CR1 though a pertussis toxin-sensitive signaling pathway. Thus, CX3CR1 has a dual function as an adhesion molecule and a signal transducer for leukocyte migration. Abundant expression of CX3CR1 in microglia and that of fractalkine in neurons also suggests important roles in the brain.

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