Organic Reactions in Water: Principles, Strategies and Applications

Description

Volatile organic solvents are the normal media used in both research scale and industrial scale synthesis of organic chemicals. Their environmental impact is significant, however, and so the development of alternative reaction media has become of great interest. Developments in the use of water as a solvent for organic synthesis have reached the point where it could now be considered a viable solvent for many organic reactions. Organic Reactions in Water demonstrates the underlying principles of using water as a reaction solvent and, by reference to a range of reaction types and systems, it’s effective use in synthetic organic chemistry. Written by an internationally respected team of contributors, and with a strong focus on the practical use of water as a reaction medium, this book illustrates the enormous potential of water for the development of new and unique chemistries and synthetic strategies, while at the same time offering a much reduced environmental impact.Content: Chapter 1 A Fifty?Year Perspective on Chemistry in Water (pages 1–28): Ronald BreslowChapter 2 Structure and Properties of Water (pages 29–59): Jan B.F.N. EngbertsChapter 3 Acid Catalysis in Water (pages 60–91): Chikako Ogawa and Shu KobayashiChapter 4 Metal?Mediated C?C Bond Formations in Aqueous Media (pages 92–145): Chao?Jun LiChapter 5 Pericyclic Reactions in Aqueous Media (pages 146–184): Francesco Fringuelli, Oriana Piermatti, Ferdinando Pizzo and Luigi VaccaroChapter 6 Catalyzed Reductions in Aqueous Media (pages 185–214): T.V. Rajanbabu and Seunghoon ShinChapter 7 Oxidations (pages 215–235): Roger A. SheldonChapter 8 Nucleophilic Additions and Substitutions in Water (pages 236–255): Denis SinouChapter 9 Reactions in Nearcritical Water (pages 256–300): C.L. Liotta, J.P. Hallett, P. Pollet and C.A. EckertChapter 10 Biocatalysis in Water (pages 301–349): Kaoru Nakamura and Tomoko MatsudaChapter 11 Chemistry ‘On Water’ – Organic Synthesis in Aqueous Suspension (pages 350–365): Sridhar Narayan, Valery V. Fokin and K. Barry SharplessChapter 12 Water as a Reaction Solvent – an Industry Perspective (pages 366–397): Ernst Wiebus and Boy Cornils