Protein-Protein Interactions

Description

Michael D. Wendt Protein-Protein Interactions as Drug Targets Shaomeng Wang , Yujun Zhao , Denzil Bernard , Angelo Aguilar , Sanjeev Kumar Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics Kurt Deshayes , Jeremy Murray , Domagoj Vucic The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer John F. Kadow , David R. Langley , Nicholas A. Meanwell , Michael A. Walker , Kap-Sun Yeung , Richard Pracitto Protein-Protein Interaction Targets to Inhibit HIV-1 Infection Nicholas A. Meanwell , David R. Langley Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion – a Focus on Respiratory Syncytial Virus Andrew B. Mahon , Stephen E. Miller , Stephen T. Joy , Paramjit S. Arora Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces Michael D. Wendt The Discovery of Navitoclax, a Bcl-2 Family Inhibitor Front Matter....Pages i-xviii Protein-Protein Interactions as Drug Targets....Pages 1-55 Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics....Pages 57-79 The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer....Pages 81-103 Protein-Protein Interaction Targets to Inhibit HIV-1 Infection....Pages 105-165 Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion: A Focus on Respiratory Syncytial Virus....Pages 167-196 Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces....Pages 197-230 The Discovery of Navitoclax, a Bcl-2 Family Inhibitor....Pages 231-258 Back Matter....Pages 259-261