Expression Profiling of Human Tumors: Diagnostic and Research Applications

Description

Global gene expression profiling is a new and comprehensive approach to the investigation of tumor biology that has the potential to sharply alter the future of cancer research, diagnostic pathology, and clinical oncology. In Expression Profiling of Human Tumors: Diagnostic and Research Applications, over 20 leading investigators offer the first thorough review of the application of this novel technology to human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. For each cancer type, the authors assess the potential of the approach in reaching more precise diagnoses, as well as in the identification of prognostic markers, therapeutic targets, and gene expression patterns that accurately predict therapeutic response. A section on the technology and its novel analytical methods explains both the theory and practice of comprehensive gene expression profiling Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications provides every cancer researcher, oncologist, pathologist, and cancer surgeon an essential introduction to the most promising high-throughput investigative approach in molecular biology today-a technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology. Front Matter....Pages i-x Front Matter....Pages 1-1 Introduction: Present and Potential Impact of Expression Profiling Studies of Human Tumors....Pages 3-7 Front Matter....Pages 9-9 cDNA Microarrays....Pages 11-21 Oligonucleotide Microarrays....Pages 23-46 Serial Analysis of Gene Expression (SAGE) in Cancer Research....Pages 47-60 Tissue Arrays....Pages 61-72 Microarray Data Analysis....Pages 73-101 The Role of Tumor Banking and Related Informatics....Pages 103-117 Front Matter....Pages 119-119 Characterization of Gene Expression Patterns for Classification of Breast Carcinomas....Pages 121-145 Microarray Analysis of Colorectal Cancer....Pages 147-171 Gene Expression Analysis of Prostate Carcinoma....Pages 173-197 Classification of Human Lung Carcinomas by mRNA Expression Profiling....Pages 199-217 Molecular Profiling of Bladder Cancer Using High-Throughput DNA Microarrays....Pages 219-233 Gene Expression Profiling of Renal Cell Carcinoma and its Clinical Implications....Pages 235-255 Expression Profiling of Pancreatic Ductal Adenocarcinoma....Pages 257-275 Gene Expression in Ovarian Carcinoma....Pages 277-294 Classification of Pediatric Tumors Using DNA Microarrays....Pages 295-304 Transcriptomes of Soft Tissue Tumors....Pages 305-327 Gene Expression Profiling in Lymphoid Malignancies....Pages 329-344 Gene Expression Profiling of Brain Tumors....Pages 345-357 Expression Profiling of Bone Tumors....Pages 359-391 Back Matter....Pages 393-399