ENGLISH

Untranslated Gene Regions and Other Non-coding Elements: Regulation of Eukaryotic Gene Expression

By Lucy W. Barrett , Sue Fletcher , Steve D. Wilton (auth.)

Book information

Publisher
Springer Basel
Year
2013
ISBN
3034806787, 9783034806787
DOI
10.1007/978-3-0348-0679-4
ISSN
2211-9353
LCC
2013940950
Language
english
Format
PDF
Filesize
2 MB (2344638 bytes)
Series
SpringerBriefs in Biochemistry and Molecular Biology
Edition
1
Pages
56\65
Topic
Biology Molecular
Orientation
yes
Paginated
yes
Scanned
portrait
Time added
2013-07-11 17:23:11
Animal Genetics and Genomics; Plant Genetics & Gen

Description

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.​

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