Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, Second Edition

Description

Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs―regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine. Content: Cover Half Title Title Page Copyright Page Dedication Table of Contents Preface to the 2nd edition Preface to the 1st edition PART I: INTRODUCTION 1: Biomaterials and Manufacturing Methods for Scaffolds in regenerative Medicine: Update 2015 1.1 Introduction 1.2 Biomaterials for Regenerative Medicine and Tissue Engineering 1.2.1 Importance of Scaffold Matrices in regenerative Medicine and tissue Engineering 1.2.2 Bioceramic Scaffolds 1.2.2.1 Calcuim phosphate 1.2.2.2 Tricalcuim phosphate (TCP) 1.2.2.3 Hydroxyapatite 1.2.2.4 Bioglass 1.2.2.5 Demineralized bone particle 1.2.5 Bioactive Molecules Release System for Regenerative Medicine and Tissue Engineering1.3 Scaffold Fabrication and Characterization 1.3.1 Fabrication Methods of Scaffolds 1.3.1.1 Electrospinning method 1.3.1.2 PGA nonwoven sheet 1.3.1.3 Porogen leaching methods 1.3.1.4 Gas foaming method 1.3.1.5 Phase separation method 1.3.1.6 Rapid prototyping 1.3.1.7 Injectable gel method 1.3.2 Physicochemical Characterization of Scaffolds 1.3.3 Sterilization Method for Scaffolds 1.4 Concluding remarks and Future Directions PART II: CERAMIC AND METAL SCAFFOLDS 2: Biomineralized Matrices as Intelligent Scaffolds for Bone Tissue Regeneration2.1 Introduction 2.1.1 Bone Tissue: A Mineralized Hierarchical Living Structure 2.1.2 Mineralized Biomaterials for Bone Tissue Repair 2.2 CaP Biomaterials 2.3 CaP-Based Biomaterial-Assisted Osteogenic Differentiation of Stem Cells 2.4 CaP Matrices for Bone Tissue Engineering and Repair 2.5 CaP Mineral-Based Matrices as a Delivery Vehicle for Growth Factors and Genes 2.6 CaP-Assisted Stem Cell Osteogenesis and Bone Tissue Regeneration: Mechanistic Insights 2.7 Conclusions and Future Perspectives 3: Bioceramic and Composite Scaffolds in Drug Delivery and Bone Tissue Engineering3.1 Introduction 3.2 Bioceramics 3.3 Nanotechnology in Bioceramics 3.4 Nanoceramics in Drug Delivery 3.5 Bone Tissue Engineering 3.6 Research Perspective 3.7 Basic Questions in Bone Tissue Engineering 3.8 Conclusions 4: Recent Developments in Materials Innovation for Bone Tissue Regeneration 4.1 Overview 4.2 Materials' Innovation 4.2.1 Bioceramics 4.2.2 Glass and Glass Ceramics 4.2.3 Biopolymers and Hydrogels 4.3 Microstructure and Morphology Optimization of Bioceramic-Based Bone Substitutes