Recent Developments in Neurodegeneration

Description

Recent Developments in Neurodegeneration discusses the diverse functions of nitric oxide regarding redox regulation, the cellular energy pool, modifications in genetic material, neurogenesis, the effects on protein degradation mechanisms and functional consociation with glial cells. The authors consider the latest evidence that demonstrates that Alzheimer’s disease-associated proteins and their genes play a key role in the post-ischemic development of neurodegeneration with dementia. The main processes associated with secondary tissue damage following traumatic injury to the nervous system are reviewed. In closing, a comprehensive investigation of the combination of tremor and olfactory perception characteristics among patients with Parkinson’s disease and essential tremor is presented. Contents Preface Chapter 1 Nitric Oxide and Cellular Homeostasis: Updates in Neurodegenerative Mechanisms Abstract Abbreviations 1. Introduction 2. NO Mediated Neurodegenerative Mechanisms 2.1. Nitric Oxide and Oxidative Stress 2.2. Nitric Oxide and Mitochondrial Dysfunction 2.3. Nitric Oxide and Protein Modification 2.4. Nitric Oxide and Endoplasmic Reticulum Stress 2.5. Nitric Oxide and Protein Degradation Mechanism 2.6. Nitric Oxide and DNA Damage 2.7. NO and Apoptosis 2.8. NO and Autophagy 2.9. NO and Glial Cells 3. Evidences for Role of NO in CNS-Neurodegenerative Diseases 3.1. Evidences for Role of NO in AD Pathology 3.2. Evidences for Role of NO in PD Pathology 3.3. Evidences for Role of NO in HD Pathology 3.4. Evidences for Role of NO in ALS Pathology Future Perspective and Conclusion References Chapter 2 Participation of Brain Ischemia in the Development of the Genotype and Phenotype of Alzheimer’s Disease Abstract Introduction Dysregulation of Amyloid Associated Genes in Post-Ischemic Brain Amyloid in Post-Ischemic Brain Dysregulation of the Tau Protein Gene in Post-Ischemic Brain Tau Protein in Post-Ischemic Brain Neuropathology in Post-Ischemic Brain Dementia Following Brain Ischemia Conclusion Acknowledgments References Chapter 3 Inflammatory Response, Excitotoxicity and Oxidative Stress Following Traumatic Brain Injury Abstract Introduction Excitotoxicity Following Brain Injury Inflammation Following Brain Injury Oxidative Stress Following Brain Injury Conclusion Acknowledgments References Biographical Sketches Chapter 4 All Around the Nose of Parkinsonism and Essential Tremor Index Blank Page