ENGLISH

Intracellular Traffic and Neurodegenerative Disorders

By Peter H. St.George-Hyslop , William C. Mobley

Book information

Publisher
Springer
Year
2008
ISBN
9783540879404, 3540879404
Language
english
Format
PDF
Filesize
12 MB (12244952 bytes)
Series
Research and Perspectives in Alzheimer's Disease
Edition
1
Pages
188\188
Topic
Medicine
Library
avaxhome.ws
Time added
2010-05-31 15:29:46

Description

This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically.В This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.

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