Mind Control Secrets

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Pt. 1. Cell death -- Pharmacological manipulation of cell death: clinical applications in sight? / Douglas R. Green and Guido Kroemer -- Pharmacological manipulation of Bcl-2 family members to control cell death / Anthony G. Letai -- Caspases: pharmacological manipulation of cell death / Inna N. Lavrik, Alexander Golks, and Peter H. Krammer -- IKK/NF-(B signaling: balancing life and death: a new approach to cancer therapy / Jun-Li Luo, Hideaki Kamata, and Michael Karin -- Reawakening the cellular death program in neoplasia through therapeutic blockade of IAP function / Casey W. Wright and Colin Duckett -- The survival kinases Akt and Pim as potential pharmacologic targets / Ravi Amaravadi and Craig Thompson -- Mitochondria: pharmacological manipulation of cell death / Lisa Bouchier-Hayes, Lydia Lartigue, and Donald Newmeyer -- Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways / Helen M. Beere -- Autophagy in cell death: an innocent convict? / Beth Levine and Junying Yuan -- Endoplasmic reticulum stress: cell life and death decisions / Chunyan Xu, Beatrice Bailly-Maitre, and John Reed Pt. 2. Oncology Dysregulation of Met receptor tyrosine kinase activity in invasive tumors / Alla Danilkovitch-Miagkova and Berton Zbar -- Integrins in invasive growth / Cord Brakebusch, Daniel Bouvard, Fabio Stanchi, Takao Sakai, and Reinhard Fassler -- Stat proteins and oncogenesis / Jacqueline Bromberg -- The cadherin-catenin adhesion system in signaling and cancer / Maralice Conacci-Sorrell, Jacob Zhurinsky, and Avri Ben-Zéev -- Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence? / Pier Giuseppe Pelicci -- When cells get stressed: an integrative view of cellular senescence / Ittai Ben-Porath and Robert A. Weinberg -- Telomeres, stem cells, senescence, and cancer / Norman E. Sharpless and Ronald A. DePinho -- Bmi1, stem cells, and senescence regulation / In-Kyung Park, Sean J. Morrison, and Michael F. Clarke -- Cellular senescence in cancer treatment: friend or foe? / Pascal Kahlem, Bernd Dorken, and Clemens A. Schmitt -- Mechanisms for pituitary tumorigenesis: the plastic pituitary / Shlomo Melmed -- Melanoma genetics and the development of rational therapeutics / Yakov Chudnovsky, Paul A. Khavari, and Amy E. Adams -- Immunopathogenesis and therapy of cutaneous T cell lymphoma / Ellen J. Kim, Stephen Hess, Stephen K. Richardson, Sara Newton, Bernice M. Benoit, Ravi Ubriani, Carmela C. Vittorio, Jacqueline M. Junkins-Hopkins, Maria Wysocka, Alain H. Rook -- Cancer vaccines: progress reveals new complexities / IFNs and STATs in innate immunity to microorganisms Thomas Decker, Silvia Stockinger, Marina Karaghiosoff, Mathias Mü̈ller, and Pavel Kovarik Pt. 3. Immune system and immune-mediated injury -- IFNs and STATs in innate immunity to microorganisms / Thomas Decker, Silvia Stockinger, Marina Karaghiosoff, Mathias M̈̈ü̈ller, and Pavel Kovarik -- Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways / Fabio Candotti, Luigi Notarangelo, Roberta Visconti, and John OʹShea -- An integrated view of suppressor T cell subsets in immunoregulation / Hong Jiang and Leonard Chess CD4+ Tregs and immune control / Zoltan Fehervari and Shimon Sakaguchi -- Tregs and allergic disease / Douglas S. Robinson, Mark Larcheʹ, and Stephen R. Durham -- Tregs and transplantation tolerance / Patrick T. Walsh, Devon K. Taylor, and Laurence A. Turka -- C-reactive protein: a critical update / Mark Pepys and Gideon Hirschfield -- New insights into atopic dermatitis / Donald Y.M. Leung, Mark Boguniewicz, Michael D. Howell, Ichiro Nomura, and Qutayba A. Hamid -- Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities / Brian J. Nickoloff and Frank O. Nestle -- Exploiting dendritic cells to improve vaccine efficacy / Ralph M. Steinman and Melissa Pope Pt. 4. Infectious diseases -- Clinical syndromes -- The enigma of sepsis / Niels C. Riedemann, Ren-Feng Guo, and Peter A. Ward -- Gram-positive bacteria in health and disease -- Antimicrobial resistance: the example of Staphylococcus aureus / Franklin D. Lowy -- Bacterial infectious disease control by vaccine development / Roy Curtiss, III -- Development of an improved vaccine for anthrax / Stephen H. Leppla, John B. Robbins, Rachel Schneerson, and Joseph Shiloach -- Gram-negative bacteria in health and disease -- Helicobacter pylori persistence: biology and disease / Martin J. Blaser and John C. Atherton -- The emergence of Lyme disease / Allen C. Steere, Jenifer Coburn, and Lisa Glickstein -- Bacterial communication -- The application of biofilm science to the study and control of chronic bacterial infections / William Costerton, Richard Veeh, Mark Shirtliff, Mark Pasmore, Christopher Post, and Garth Ehrlich -- Quorum sensing in Staphylococcus infections / Jeremy M. Yarwood and Patrick M. Schlievert -- Quorum sensing and biofilm formation in Streptococcal infections / Dennis G. Cvitkovitch, Yung-Hua Li, and Richard P. Ellen -- Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections / Morten Hentzer and Michael Givskov -- Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target / Roger S. Smith and Barbara H. Iglewski -- Protozoal Infections -- Antimalarial drug resistance / Nicholas J. White -- Parasitic infections -- Human African trypanosomiasis of the CNS: current issues and challenges / Peter G.E. Kennedy Pt. 5. Viral diseases -- SARS coronavirus: a new challenge for prevention and therapy / Kathryn Holmes -- Acute HIV revisited: new opportunities for treatment and prevention / Christopher D. Pilcher, Joseph J. Eron Jr., Shannon Galvin, Cynthia Gay, and Myron S. Cohen -- Strategies for an HIV vaccine / Norman L. Letvin -- Dengue: defining protective versus pathologic immunity / Alan L. Rothman -- West Nile virus: a growing concern? / L. Hannah Gould and Erol Fikrig -- Progress on new vaccine strategies against chronic viral infections / Jay A. Berzkofsky, Jeffrey D. Ahlers, John Janik, John Morris, SangKon Oh, Masaki Terabe, and Igor M. Belyakov -- Entry of parainfluenza virus entry into cells as a target for interrupting childhood respiratory disease / Anne Moscona -- Influenza vaccines: present and future / Peter Palese and Adolfo Garcøa-Sastre -- Live-attenuated virus vaccines for respiratory syncytial and para influenza viruses: applications of reverse genetics / Brian R. Murphy and Peter L. Collins -- Herpes simplex viruses: is a vaccine tenable? / Richard J. Whitley and Bernard Roizman -- Prophylactic human papillomavirus vaccines / Douglas R. Lowy and John T. Schiller Pt. 6. Respiratory system -- Disorders of lung matrix remodeling / Harold A. Chapman -- New insights into the pathogenesis of asthma / Jack A. Elias, Chun Geun Lee, Tao Zheng, Bing Ma, Robert J. Homer, and Zhou Zhu -- JAK-STAT signaling in asthma / Alessandra B. Pernis and Paul B. Rothman -- Rescuing protein conformation: prospects for pharmacological therapy in cystic fibrosis / Marina S. Gelman and Ron R. Kopito -- Epithelial-mesenchymal transition and its implications for fibrosis Raghu Kalluri and Eric G. Neilson Pt. 7. Cardiovascular system -- Oxygen, oxidative stress, hypoxia, and heart failure / Frank J. Giordano -- NO/redox disequilibrium in the failing heart and cardiovascular system / Joshua M. Hare and Jonathan S. Stamler -- Genetic causes of human heart failure / Hiroyuki Morita, Jonathan Seidman, and Christine E. Seidman -- Protein kinase cascade in the regulation of cardiac hypertrophy / Gerald W. Dorn II and Thomas Force -- Toward transcriptional therapies for the failing heart: chemical screens to modulate genes / Timothy A. McKinsey and Eric N. Olson -- Mitochondrial energy metabolism in heart failure: a question of balance / Janice M. Huss and Daniel P. Kelly -- Death begets heart failure / Roger S.-Y. Foo, Kartik Mani, and Richard N. Kitsis -- Unchain my heart: the scientific foundations of cardiac repair / Stefanie Dimmeler, Andreas M. Zeiher, and Michael D. Schneider -- Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities / Garret A.Fitzgerald -- Sex is a potent modifier of the cardiovascular system / Leslie Leinwand -- Vascular Diseases -- Cholesterol in health and disease / Ira Tabas -- Cholesterol, lipid rafts, and disease / Kai Simons and Robert Ehehalt -- Malformation syndromes due to inborn errors of cholesterol synthesis / Forbes D. Porter -- Intracellular cholesterol transport / Frederick R. Maxfield and Daniel Wüstner -- Regulation and mechanisms of macrophage cholesterol efflux / Alan R. Tall, Philippe Costet, and Nan Wang -- Consequences of cellular cholesterol accumulation: basic concepts and physiological implications / Ira Tabas -- Monogenic hypercholesterolemia: new insights in pathogenesis and treatment / Daniel J. Rader, Jonathan Cohen, and Helen H. Hobbs -- Isoprenoids as mediators of the biological effects of statins / James K. Liao -- Disorders of rhythm -- The channelopathies: novel insights into molecular and genetic mechanisms of human disease / Robert Kass -- Mechanisms of sudden cardiac death / Michael Rubart and Douglas P. Zipes -- Long QT syndrome: from channels to cardiac arrhythmias / Arthur J. Moss and Robert Kass -- Genetics of acquired long QT syndrome / Dan M. Roden -- Muscle channelopathies and critical points in functional and genetic studies / Karin Jurkat-Rott and Frank Lehmann-Horn -- Inherited disorders of voltage-gated sodium channels Alfred L. George, Jr. -- Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels / Silvia G. Priori and Carlo Napolitano -- Chloride channel diseases resulting from impaired transepithelial transport or vesicular function / Thomas J. Jentsch, Tanja Maritzen, and Anselm A. Zdebik Pt. 8. Hematology -- Megakaryocyte biology and related disorders / Liyan Pang, Mitchell J. Weiss, and Mortimer Poncz -- The molecular mechanisms that control thrombopoiesis / Kenneth Kaushansky -- Thrombus formation in vivo / Bruce Furie and Barbara C. Furie -- Platelet genomics and proteomics in human health and disease / Ian C. Macauley, Philippa Carr, Arief Gusnanto, Willem H. Ouwehand, Des Fitzgerald, and Nicholas A. Watkins -- The biogenesis of platelets from megakaryocyte proplatelets / Sunita R. Patel, John H. Hartwig, and Joseph Italiano -- Platelets in inflammation and atherogenesis / Meinrad Gawaz, Harald Langer, and Andreas E. May -- Structure and function of the platelet integrin [alpha] IIb [beta]3 / Joel S. Bennett Minding the gaps to promote thrombus growth and stability / Lawrence F. Brass, Li Zhu, and Timothy J. Stalker -- Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood / Joanne Kurtzberg, Anne Drapkin Lyerly, and Jeremy Sugarman Pt. 9. Gastrointestinal system -- Intestinal ion transport and the pathophysiology of diarrhea / Michael Field -- Molecular mediators of hepatic steatosis and liver injury / Jeffrey D. Browning and Jay D. Horton -- Liver fibrosis / Ramon Bataller and David A. Brenner -- SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver / Jay D. Horton, Joseph L. Goldstein, and Michael S. Brown Pt. 10. Endocrinology and metabolism -- Genetic epidemiology of diabetes / M. Alan. Permutt, Jonathan Wasson, and Nancy Cox -- ATP-sensitive potassium channelopathies: focus on insulin secretion / Frances M. Ashcroft -- Gestational diabetes mellitus / Thomas A. Buchanan and Anny H. Xiang -- Regeneration of the pancreatic [beta] cell / Massimo Trucco -- Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus / Kristina I. Rother and David M. Harlan -- How does blood glucose control with insulin save lives in intensive care? / Greet Van den Berghe -- Thyrotropin receptor associated diseases: from adenomata to Graves disease / Terry F. Davies, Takao Ando, Reigh-Yi Lin, Yaron Tomer and Rauf Latif -- Inflammation, stress, and diabetes / Kathryn E. Wellen and Gokhan S. Hotamisligil -- Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome / Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota, Kazuo Hara, Kohjiro Ueki, and Kazuyuki Tobe -- The role of cholesterol efflux in regulating the fertilization potential of mammalian spermatozoa / Alexander J. Travis and Gregory S. Kopf -- Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface / Susan Fisher Pt. 11. Kidney and urinary tract -- Acute renal failure: definitions, diagnosis, pathogenesis, and therapy / R.W. Schrier, W. Wang, B. Poole, and A. Mitra -- Kidney stone disease / Fredric L. Coe, Andrew Evan, and Elaine Worcester -- Salt handling and hypertension / Kevin M. O̕ Shaughnessy and Fiona E. Karet Pt. 12. Bone and mineral metabolism -- Pathogenesis of osteoporosis: concepts, conflicts, and prospects / Lawrence G. Raisz -- Paget disease of bone / G. David Roodman and Jolene J. Windle -- Estrogen deficiency and bone loss: an inflammatory tale / M. Neale Weitzmann and Roberto Pacifici -- Regulation of bone mass by Wnt signaling / Venkatesh Krishnan, Henry U. Bryant, and Ormond A. MacDougald Pt. 13. Neurologic disorders VEGF: a critical player in neurodegeneration / Erik Storkebaum and Peter Carmeliet -- Neurogenesis and brain injury: managing a renewable source for repair / Daniel Peterson -- Oxidative stress, cell cycle, and neurodegeneration / Jeffrey A. Klein and Susan L. Ackerman -- Neuronal degeneration and mitochondrial dysfunction / Eric A. Schon and Giovanni Manfredi -- The role of cerebral amyloid [beta] accumulation in common forms of Alzheimer disease / Sam Gandy -- Alzheimer disease therapy: can the amyloid cascade be halted? / Todd E. Golde -- Diagnosis and treatment of Parkinson disease: molecules to medicine / Joseph M. Savitt, Valina L. Dawson, and Ted M. Dawson -- Huntingtin in health and disease / Anne B. Young -- Programmed cell death in amyotrophic lateral sclerosis / Christelle Gue̓̓̓gan and Serge Przedborski -- Multiple sclerosis / David A. Hafler -- Progress and problems in the biology, diagnostics, and therapeutics of prion diseases / Adriano Aguzzi, Mathias Heikenwalder, and Gino Miele -- The genetic epidemiology of neurodegenerative disease / Lars Bertrum and Rudolf Tanzi -- Sodium channels in epilepsy and other neurological disorders / Miriam Meisler and Jennifer Kearney -- Finding schizophrenia genes / George Kirov, Michael O̕ Donovan, and Michael Owen -- The addicted human brain: insights from imaging studies / Nora D. Volkow, Joanna S. Fowler, and Gene-Jack Wang Pt. 14. Genetics and disease -- Mapping the new frontier complex genetic disorders / Richard Mayeux -- Mapping quantitative trait loci in humans: achievements and limitations / Partha Majumder and Saurabh Ghosh -- / Newtown Morton -- Genetic counselors: translating genomic science into clinical practice / Robin L. Bennett, Heather L. Hampel, Jessica B. Mandell, and Joan H. Marks -- Genetic counseling throughout the life cycle / Leslie J. Ciarleglio, Robin L. Bennett, Jennifer Williamson, Jessica B. Mandell, and Joan H. Marks -- Payment of clinical research subjects / Christine Grady -- Embryonic death and the creation of human embryonic stem cells / Donald W. Landry and Howard A. Zucker -- Stem cells: science, policy, and ethics / Gerald D. Fischbach and Ruth L. Fischbach.