ENGLISH

Biomarkers in Breast Cancer (Cancer Drug Discovery and Development)

By Daniel F. Hayes , Giampietro Gasparini

Book information

Publisher
Humana Press
Year
2005
ISBN
1588292274, 9781588292278
LCC
RC280.B8 B54 2006
Open Library ID
OL19152169M
Language
english
Format
PDF
Filesize
4 MB (3846617 bytes)
Edition
1
Pages
360\355
Topic
Biology Biophysics
Time added
2011-06-04 13:46:07

Description

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

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