ENGLISH

The Chemical Biology of DNA Damage

Book information

ISBN
9783527322954, 9783527630110
DOI
10.1002/9783527630110
Language
english
Format
PDF
Filesize
6 MB (6199599 bytes)
Pages
462\462
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

Content: Chapter 1 Introduction and Perspectives on the Chemistry and Biology of DNA Damage (pages 1–20): Prof. Nicholas E. Geacintov and Prof. Suse BroydeChapter 2 Chemistry of Inflammation and DNA Damage: Biological Impact of Reactive Nitrogen Species (pages 21–51): Michael S. De Mott and Peter C. DedonChapter 3 Oxidatively Generated Damage to Isolated and Cellular DNA (pages 53–80): Jean Cadet, Thierry Douki and Jean?Luc RavanatChapter 4 Role of Free Radical Reactions in the Formation of DNA Damage (pages 81–104): Vladimir Shafirovich and Nicholas E. GeacintovChapter 5 DNA Damage Caused by Endogenously Generated Products of Oxidative Stress (pages 105–130): Charles G. Knutson and Lawrence J. MarnettChapter 6 Polycyclic Aromatic Hydrocarbons: Multiple Metabolic Pathways and the DNA Lesions Formed (pages 131–155): Trevor M. PenningChapter 7 Aromatic Amines and Heterocyclic Aromatic Amines: From Tobacco Smoke to Food Mutagens (pages 157–183): Robert J. TureskyChapter 8 Genotoxic Estrogen Pathway: Endogenous and Equine Estrogen Hormone Replacement Therapy (pages 185–199): Judy L. Bolton and Gregory R. J. ThatcherChapter 9 Interstrand DNA Cross?Linking 1,N2?Deoxyguanosine Adducts Derived from ?,??Unsaturated Aldehydes: Structure–Function Relationships (pages 201–216): Michael P. Stone, Hai Huang, Young?Jin Cho, Hye?Young Kim, Ivan D. Kozekov, Albena Kozekova, Hao Wang, Irina G. Minko, R. Stephen Lloyd, Thomas M. Harris and Carmelo J. RizzoChapter 10 Structure–Function Characteristics of Aromatic Amine?DNA Adducts (pages 217–238): Bongsup ChoChapter 11 Mechanisms of Base Excision Repair and Nucleotide Excision Repair (pages 239–260): Orlando D. Scharer and Arthur J. CampbellChapter 12 Recognition and Removal of Bulky DNA Lesions by the Nucleotide Excision Repair System (pages 261–298): Yuqin Cai, Konstantin Kropachev, Marina Kolbanovskiy, Alexander Kolbanovskiy, Prof. Suse Broyde, Dinshaw J. Patel and Prof. Nicholas E. GeacintovChapter 13 Impact of Chemical Adducts on Translesion Synthesis in Replicative and Bypass DNA Polymerases: From Structure to Function (pages 299–330): Robert L. Eoff, Martin Egli and Peter GuengerichChapter 14 Elucidating Structure–Function Relationships in Bulky DNA Lesions: From Solution Structures to Polymerases (pages 331–352): Prof. Suse Broyde, Lihua Wang, Dinshaw J. Patel and Prof. Nicholas E. GeacintovChapter 15 Translesion Synthesis and Mutagenic Pathways in Escherichia coli Cells (pages 353–380): Sushil Chandani and Edward L. LoechlerChapter 16 Insight into the Molecular Mechanism of Translesion DNA Synthesis in Human Cells using Probes with Chemically Defined DNA Lesions (pages 381–397): Zvi LivnehChapter 17 DNA Damage and Transcription Elongation: Consequences and RNA Integrity (pages 399–437): Kristian Dreij, John A. Burns, Alexandra Dimitri, Lana Nirenstein, Taissia Noujnykh and David A. Scicchitano

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