The Molecular Basis of Human Cancer

Description

This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer. Front Matter....Pages i-xix Cancer Epidemiology: Incidence and Etiology of Human Neoplasms....Pages 1-24 Essential Concepts and Techniques in Molecular Biology....Pages 25-42 Cancer Genomics....Pages 43-63 Cancer Cytogenetics....Pages 65-82 Epigenetic Basis of Human Cancer....Pages 83-102 Cancer Proteomics....Pages 103-119 An Overview of Cancer Genes....Pages 121-142 Oncogenes and the Initiation and Maintenance of Tumorigenesis....Pages 143-157 Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors....Pages 159-182 Senescence, Apoptosis, and Cancer....Pages 183-196 Novel Cancer Therapies Targeting Angiogenesis....Pages 197-202 Beyond the Primary Tumor: Progression, Invasion, and Metastasis....Pages 203-216 Simple Sequence Mutations....Pages 217-230 Single Nucleotide Polymorphisms and Cancer Susceptibility....Pages 231-239 Chromosomes and Chromosomal Instability in Human Cancer....Pages 241-262 Epigenetic Mechanisms in Cancer Development....Pages 263-275 MicroRNAs and Cancer....Pages 277-286 Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas....Pages 287-295 Viral Mechanisms in Human Carcinogenesis....Pages 297-306 Hormonal Carcinogenesis: The Role of Estrogens....Pages 307-322 Sporadic Cancers....Pages 323-334 Hereditary Cancer....Pages 335-353 Retinoblastoma: Clinical and Molecular Perspectives....Pages 355-361 Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light....Pages 363-380 Hereditary Colorectal Cancer....Pages 381-400 Hereditary Breast and Ovarian Cancer....Pages 401-421 The Molecular Basis of Prostate Carcinogenesis....Pages 423-445 Molecular Basis of Lung Carcinogenesis....Pages 447-496 Molecular Basis of Skin Carcinogenesis....Pages 497-503 Molecular Biology of Leukemias....Pages 505-559 Molecular Mechanisms in Non-Hodgkin Lymphoma....Pages 561-587 The Molecular Pathology of Head and Neck Squamous Cell Carcinoma....Pages 589-601 Ovarian Cancer....Pages 603-621 Molecular Pathology of Bone and Soft Tissue Tumors....Pages 623-655 Molecular Biology of Human Brain Tumors....Pages 657-694 Cancer Drug Discovery and Anticancer Drug Development....Pages 695-707 Biological Principles and Clinical Application of EGFR Inhibitors in Cancer....Pages 709-726 Targeting Oncoproteins for Molecular Cancer Therapy....Pages 727-756 Therapeutic Agents That Inhibit Angiogenesis....Pages 757-769 Small Molecule Inhibitors....Pages 771-795 Molecular Detection and Diagnosis of Cancer....Pages 797-809 Gene Therapy in the Treatment of Human Cancer....Pages 811-841 Personalized Medicine for the Treatment of Human Cancer....Pages 843-855 Back Matter....Pages 857-873