Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives

Description

Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields. Content: Chapter 1 Natural Products in Drug Discovery: Recent Advances (pages 1–42): Gordon M. Cragg, Paul G. Grothaus and David J. NewmanChapter 2 Modern Approaches in the Search for New Active Compounds from Crude Extracts of Natural Sources (pages 43–80): Emerson F. Queiroz, Kurt Hostettmann and Jean?Luc WolfenderChapter 3 Natural Products as Lead Compounds in Medicinal Chemistry (pages 81–126): Eliezer J. Barreiro, Carlos A. M. Fraga and Lidia M. LimaChapter 4 The Importance of Structural Manipulation of Natural Compounds in Drug Discovery and Development (pages 127–160): Arturo San Feliciano, Maria A. Castro, Jose L. Lopez?Perez and Esther del OlmoChapter 5 The Action of Plants and their Constituents on the Central Nervous System (pages 161–204): Fulvio R. Mendes Giuseppina Negri, Joaquim M. Duarte?Almeida, Ricardo Tabach and Elisaldo A. CarliniChapter 6 The Role of Natural Products in Discovery of New Anti?Infective Agents with Emphasis on Antifungal Compounds (pages 205–239): Maximiliano Sortino, Marcos Derita, Laura Svetaz, Marcela Raimondi, Melina Di Liberto, Elisa Petenatti, Mahabir Gupta and Susana ZacchinoChapter 7 Antiulcer Agents from Higher Plants (pages 241–262): Luiz C. Klein?Junior, Jose R. Santin and Sergio F. de AndradeChapter 8 Recent Progress in the Chemistry and Biology of Paclitaxel (TaxolTM) and Related Taxanes (pages 263–336): Jun Qi, Jielu Zhao and David G. I. KingstonChapter 9 Cancer Chemopreventive Activity of Higher Plants (pages 337–357): A. Douglas Kinghorn, Yulin Ren, Jie Li and Chung Ki SungChapter 10 Medicinal Plants and Pharmaceutical Technology (pages 359–393): Ruth M. Lucinda da Silva, Angelica G. Couto and Tania M. B. BresolinChapter 11 Natural Products in Clinical Trials (pages 395–417): Sigrun ChrubasikChapter 12 The Influence of Biotic and Abiotic Factors on the Production of Secondary Metabolites in Medicinal Plants (pages 419–452): Dayana R. Gouvea, Leonardo Gobbo?Neto and Norberto P. LopesChapter 13 Production of Bioactives Compounds: The Importance of Pictet–Spengler Reaction in the XXI Century (pages 453–487): Pilar Menendez, Ilaria D'Acquarica, Giuliano Delle Monache, Francesca Ghirga, Andrea Calcaterra, Marco Barba, Alberto Macone, Alberto Boffi, Alessandra Bonamore and Bruno BottaChapter 14 Screening Methods for Drug Discovery from Plants (pages 489–498): Alan L. HarveyChapter 15 Phytotherapeutics – Intellectual Property Rights, Global Market, and Global Regulatory Guidelines (pages 499–527): James D. McChesney, Raymond Cooper and Kip VoughtChapter 16 Cooperation between the Pharmaceutical Industry and Academic Institutions in Drug Discovery (pages 529–544): Valdir Cechinel?Filho, Rivaldo Niero and Rosendo A. Yunes