Nitric Oxide and Inflammation

Description

Literally thousands of papers have been published on nitric oxide over the past ten years. But there is no single monograph available that has previously attempted to summarize the important features of the roles of nitric oxide in inflammation. The voluminous literature regarding the incredible range of chemical and biological effects of nitric oxide and reactive nitrogen oxide species, RNOS, may present a tangle of confusing information to the researcher. This volume brings together experts from nitric oxide and inflammation research and presents a concise up-to-date overview as well as future aspects of this rapidly growing field. Front Matter....Pages i-xii Regulation of the inducible nitric oxide synthase (iNOS) gene....Pages 1-26 Superoxide anion release from inducible nitric oxide synthase....Pages 27-39 Direct and indirect modulation of the inducible nitric oxide synthase by nitric oxide: feedback mechanisms in inflammation....Pages 41-58 Nitric oxide regulation of eicosanoid production....Pages 59-75 Local and systemic inflammation: role of poly (ADP-ribose) synthetase activation by reactive nitrogen species....Pages 77-98 Nitric oxide regulation of leukocyte adhesion molecule expression....Pages 99-116 Nitric oxide and leukocyte recruitment....Pages 117-130 Nitric oxide regulation of lymphocyte function....Pages 131-143 Role of nitric oxide and reactive oxygen species in arthritis....Pages 145-160 Role of nitric oxide in chronic gut inflammation....Pages 161-177 Nitric oxide and inflammatory disorders of the skin....Pages 179-190 Roles of nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury and ischemic preconditioning....Pages 191-206 Nitric oxide and myocarditis....Pages 207-223 Nitric oxide in shock: sepsis and hemorrhage....Pages 225-248 Nitric oxide as a mediator of interleukin-2 induced cardiovascular toxicity and antitumor activity....Pages 249-272 Back Matter....Pages 273-279