ENGLISH

Peptide Research Protocols, Endothelin. Chapters 1-3 are absent

By Janet J. Maguire , Anthony P. Davenport

Book information

Publisher
Humana Press
Year
2002
ISBN
9780896039933, 0896039935
Open Library ID
OL17047530M
Language
english
Format
RAR
Filesize
2 MB (2269410 bytes)
Series
Methods in Molecular Biology, vol.206
Edition
1st
Pages
242\0
Topic
Biology
Library
molbiol
Time added
2009-07-20 18:31:13

Description

A panel of multidisciplinary experts describes in detail readily reproducible methods to investigate all aspects of the endothelin system from its synthesis and metabolism, to its function in health and disease. Theses methods use state-of-the-art molecular techniques to quantify the expression of mRNA for both endothelin receptors and the endothelin converting enzymes. They show how peptides, precursors, receptors, and synthetic enzymes can be localized and quantified in plasma, culture supernatants, tissue homogenate, and tissue sections using antibodies. Several in vivo protocols illustrate the role of the endothelin peptides in healthy human individuals and describe animal models that can be used to predict the therapeutic potential of cardiovascular drugs that manipulate endothelin synthesis or function.

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