The Geometric Induction of Bone Formation

Description

Cover Half Title Title Page Copyright Page Dedication Table of Contents Acknowledgements Author List of Contributors Introduction Chapter 1 The New Frontiers in Bone Tissue Engineering: Functionalized Biomimetic Surfaces beyond Morphogens and Stem Cells 1.1 Tissue Induction and Morphogenesis 1.2 The Concavity: The Shape of Life Acknowledgements References Chapter 2 The Induction of Bone Formation: When and Why Bone Forms and Sometimes Repairs and Regenerates: The Enigmatic Myth of Bone Tissue Engineering and the Dream of Regenerative Medicine 2.1 The Induction of Bone Formation 2.2 Molecular Redundancy and the Induction of Bone Formation by the Human Transforming Growth Factor-β3 2.3 Translational Research on the Recombinant Transforming Growth Factor-β3 in Human Patients 2.4 Molecular Microenvironments Super Activated by Morphogenetic Signals 2.5 Diffusible Signals, Microenvironments and the Establishment of Morphogenetic Gradients References Chapter 3 The Induction of Bone Formation and the Osteogenic Proteins of the Transforming Growth Factor-β Supergene Family: Pleiotropism and Redundancy 3.1 Why Bone? 3.2 Morphogens and the Induction of Bone Formation 3.3 The Osteogenic Proteins of the Transforming Growth Factor-β Supergene Family References Chapter 4 Coral-Derived Hydroxyapatite-Based Macroporous Bioreactors Initiate the Spontaneous Induction of Bone Formation in Heterotopic Extraskeletal Sites: Morphological Time Studies 4.1 Self-Inducing Osteoinductive Biomimetic Matrices 4.2 Tissue Induction and Morphogenesis by Coral-Derived Hydroxyapatite Constructs on Day 15 after Heterotopic Rectus Abdominis Implantation 4.3 Tissue Induction and Morphogenesis by Coral-Derived Hydroxyapatite Constructs on Days 60 and 90 after Heterotopic Rectus Abdominis Implantation 4.4 Angiogenesis, Capillary Sprouting and the Induction of Bone Formation Acknowledgements References Chapter 5 Concavities of Crystalline Sintered Hydroxyapatite-Based Macroporous Bioreactors Initiate the Spontaneous Induction of Bone Formation 5.1 Introduction 5.2 Self-Inductive Biomaterials 5.3 Surface Geometry Regulates Bone Differentiation in Heterotopic Sites 5.4 The Geometric Design of the Concavity Regulates the Induction of Bone Formation 5.5 The Concavity: The Shape of Life – Perspective and Limitations 5.6 Chondrogenesis in Biomimetic Calcium Phosphate-Based Bioreactors Acknowledgements Bibliography Chapter 6 Molecular Pathways Regulating the Geometric Induction of Bone Formation: Synthetizing and Embedding Osteogenic Proteins into Nanotopographic Geometries 6.1 Introduction 6.2 Tissue Patterning of Geometric Constructs: Morphological and Molecular Observations 6.3 Mechanistic Insights into the Induction of Bone Formation by 7% HA/CC Macroporous Bioreactors 6.4 Conclusion References Chapter 7 The Spontaneous Induction of Bone Formation by Intrinsically Osteoinductive Bioreactors for Human Patients: Osteoinductive Hydroxyapatite-Coated Titanium Implants 7.1 Geometry and the Rationale for Fabricating Self-Inducing Osteoinductive Hydroxyapatite-Coated Titanium Implants 7.2 Solid Titanium Bioreactors with the Concavity Motif 7.3 Does Pure Titanium Metal per se Initiate the Spontaneous Induction of Bone Formation? 7.4 The Geometric Induction of Bone Formation 7.5 Inducive Morphogenetic Gradients of the Concavity References Index