Irreversible Electroporation in Clinical Practice

Description

This book provides a comprehensive overview of the clinical use of irreversible electroporation (IRE) – better known by its commercial name, NanoKnife – which is one of the most exciting new needle-guided cancer treatments. The coverage includes the history of IRE, general technique, preclinical research, applications in clinical practice and early clinical results, and future perspectives. Contraindications, treatment planning, potential complications, follow-up imaging, and other practical aspects are fully discussed, with highlighting of useful tips and tricks. Through the delivery of short but highly intense electrical pulses, IRE results in tumor cell membrane permeabilization, causing cells to go into apoptosis. The minimally invasive nature of IRE, combined with the prospect of completely eradicating tumors while preserving delicate structures in the ablation zone, makes IRE the object of worldwide clinical research. This book will be of value for practitioners and trainees in interventional and diagnostic radiology, surgery, medical oncology, HPB and gastroenterology, urology, and radiation oncology. Front Matter ....Pages i-vi Front Matter ....Pages 1-1 History of Image-Guided Tumor Ablation (Hester J. Scheffer)....Pages 3-11 History of Electroporation (Andrea Rolong, Rafael V. Davalos, Boris Rubinsky)....Pages 13-37 Front Matter ....Pages 39-39 Multi-scale Biophysical Principles in Clinical Irreversible Electroporation (Daniel C. Sweeney, Robert E. Neal II, Rafael V. Davalos)....Pages 41-66 Numerical Modelling for Prediction and Evaluation of Treatment Outcome (Bor Kos, Damijan Miklavčič)....Pages 67-80 The Effect of Irreversible Electroporation on Blood Vessels, Bile Ducts, Urinary Tract, Intestines, and Nerves (Jantien A. Vogel, Laurien G. P. H. Vroomen, Govindarajan Srimathveeravalli)....Pages 81-94 Front Matter ....Pages 95-95 Anesthetic Management During Irreversible Electroporation Procedures (Jenny M. Vieveen, R. Arthur Bouwman)....Pages 97-103 Complications and Procedures to Enhance Safety (Laurien G. P. H. Vroomen, K. Nielsen, A. H. Ruarus, Hester J. Scheffer)....Pages 105-114 Treatment Planning, Needle Insertion, Image Guidance, and Endpoint Assessment (Lukas Philipp Beyer, Philipp Wiggermann)....Pages 115-120 Thermal Effects of Irreversible Electroporation (Eran van Veldhuisen, J. A. Vogel, J. H. Klaessens, R. M. Verdaasdonk)....Pages 121-136 Front Matter ....Pages 137-137 Irreversible Electroporation of Liver Tumors (Karin Nielsen, Hester J. Scheffer, M. Petrousjka van den Tol, Anders Nilsson)....Pages 139-166 Irreversible Electroporation of Pancreatic Tumors (Martijn R. Meijerink, Anders Nilsson, Govindarajan Narayanan, Robert Martin)....Pages 167-190 Irreversible Electroporation for Perihilar Cholangiocarcinoma (Klatskin Tumors) (Eva Roos, Laurien G. P. H. Vroomen, Eran van Veldhuisen, Robert-Jan Coelen, Thomas M. van Gulik, Martijn R. Meijerink)....Pages 191-200 Irreversible Electroporation of Kidney Tumours (Jim Koukounaras, Helen Kavnoudias, Kenneth R. Thomson)....Pages 201-213 Irreversible Electroporation of Prostate Tumors (Matthijs Scheltema, Jean de la Rosette)....Pages 215-222 Irreversible Electroporation of Tumors Within the Pelvic Cavity (Martijn R. Meijerink, Nicole van Grieken, Laurien G. P. H. Vroomen)....Pages 223-238 Irreversible Electroporation of Lung Tumors (H. Kodama, Govindarajan Srimathveeravalli, S. B. Solomon)....Pages 239-245 Front Matter ....Pages 247-247 From Local to Systemic Treatment: Leveraging Antitumor Immunity Following Irreversible Electroporation (Anita G. M. Stam, Tanja D. de Gruijl)....Pages 249-270 Future Perspectives of IRE (Martijn R. Meijerink, Hester J. Scheffer, Govindarajan Naranayan)....Pages 271-280 Back Matter ....Pages 281-285