Precision Molecular Pathology of Liver Cancer

Description

This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma. Front Matter ....Pages i-xi Etiology and Pathogenesis of Hepatocellular Carcinoma (Tony S. Brar, Eric Hilgenfeldt, Consuelo Soldevila-Pico)....Pages 1-15 Histologic Classification of Hepatocellular Carcinoma and Its Clinical Implications (Amy Leigh Collinsworth)....Pages 17-32 Molecular Classification of Hepatocellular Carcinoma and Precision Medicine (Michael Feely)....Pages 33-47 Genomics Studies in Hepatocellular Carcinoma via Next-Generation Sequencing (Xiyang Wei, Niya Liu, Xin Wei Wang, Junfang Ji)....Pages 49-68 Epigenetic Regulations in the Pathogenesis of HCC and the Clinical Application (Williams Puszyk, Keith Robertson, Chen Liu)....Pages 69-93 Biomarker Discovery and Validation in HCC Diagnosis, Prognosis, and Therapy (Lanjing Zhang)....Pages 95-113 Imaging of Hepatocellular Carcinoma (Naziya Samreen, Joseph R. Grajo)....Pages 115-130 Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma (Jeannette Huaman, Cuong Bach, Adeodat Ilboudo, Olorunseun O. Ogunwobi)....Pages 131-152 Hepatocellular Carcinoma Metastasis and Circulating Tumor Cells (Kien Pham, Dan Delitto, Chen Liu)....Pages 153-173 Immune Regulation in HCC and the Prospect of Immunotherapy (Joydeep Chakraborty, Eric Hilgenfeldt, Roniel Cabrera)....Pages 175-194 Liver Cell Dysplasia and the Development of HCC (Jesse Kresak, Naziheh Assarzadegan)....Pages 195-211 Locoregional Therapies for Hepatocellular Carcinoma (Beau Toskich)....Pages 213-233 The Future Prospect of Targeted Therapy in Hepatocellular Carcinoma (Stephanie H. Greco, Kristen Spencer, Darren R. Carpizo)....Pages 235-262 Back Matter ....Pages 263-271