Collagenase in Dupuytren Disease

Description

This book offers detailed guidance on the use of collagenase, or enzymatic fasciotomy, as a nonsurgical treatment for Dupuytren’s contracture and explains its role in relation to the other forms of treatment, including open fasciectomy, needle aponeurotomy, and lipofilling. Clear guidance is provided on technique, current indications, and off-label usage. With the help of tips and tricks from leading experts, the reader will learn how to personalize the procedure to meet the needs of individual patients. Advice is also provided on all aspects of rehabilitation, which is a key determinant of treatment outcome. Collagenase treatment of Dupuytren’s disease has the benefits of low invasiveness and rapid patient recovery and achieves reasonable recurrence-free periods. It is especially valuable in patients with rapid recurrence following surgery. In documenting and appraising every aspect of its use, this book will be of value for all who treat patients with Dupuytren’s disease, including hand surgeons, orthopedists, plastic surgeons, physiatrists, and physiotherapists. Front Matter ....Pages i-xi Biochemistry and Mechanism of Action of Collagenase on Collagen (Marie A. Badalamente, Gregory A. Lamaris)....Pages 1-6 Collagenase: Preclinical Evaluation and Clinical Trials in the USA and Australia (Marie A. Badalamente, Lawrence C. Hurst)....Pages 7-16 The Normal Fibrous Skeleton of the Hand and Changes in Dupuytren’s Contracture (Martin Franz Langer, Frank Unglaub)....Pages 17-38 Collagenase in Europe from the Experimental Phase to Practical Use (José M. Arandes-Renú, Rafael Sanjuán-Cerveró, Ignacio Moya-Molinas)....Pages 39-74 Preparation, Injection and Traction Procedures (Pearls and Tips and Tricks): Technical Evolution and Results in Severe Cases (Giorgio Pajardi, Chiara Parolo)....Pages 75-87 Dupuytren’s Disease of the Thumb and First Web (Lawrence C. Hurst, Nathan A. Monaco)....Pages 89-98 Rehabilitation After Treatment (Simone Seppi, Elena Marta Mancon, Rossella Pagliaro)....Pages 99-107 Follow-up Studies, Satisfaction, Recurrence, Dosage and Drug Safety (David Warwick)....Pages 109-117 American and European Regulations (Giorgio Pajardi, C. Parolo, S. Willbrand, L. Hurst, L. B. Grablutz)....Pages 119-130 Collagenase: Future Perspectives (S. Wilbrand)....Pages 131-142