Cell Biology of the Ovary
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Description
This unique compilation focuses on a very curious organ, the ovary. There are still many unknown facts about the origins of ovarian tissue and ovarian cancer, and each chapter describes in detail the latest insights into the ovary from basic to clinical aspects. Expert authors reveal the most recent findings on ovariogenesis and ovarian carcinogenesis by shedding light on stem cell biology for the ovarian surface epithelial cells or primordial germ cells. Readers will greatly increase their understanding of the relevance of the cells that constitute the ovary, which is of vast significance in comprehending the occurrence mechanism of ovarian tissue and ovarian cancer. In this way the book covers a wide range of fields concerned with the ovary. This work benefits not only gynecologists and obstetricians, but also basic researchers in the field of stem cell biology and all clinicians who are involved in the management of fertility preservation or ovarian cancer. Front Matter ....Pages i-viii Reconstitution of Germ Cell Development In Vitro (Shihori Yokobayashi, Mitinori Saitou)....Pages 1-19 The Role of Hedgehog-BMP4 Signaling in the Patterning of Coelomic Mesoderm and the Onset of Gonadogenesis (Takashi Yoshino)....Pages 21-33 Regulation of Metabolic Pathways in Steroidogenic Cells by Ad4BP/SF-1 (Ken-ichirou Morohashi, Miki Inoue, Bing Li, Takashi Baba)....Pages 35-43 Role of Lgr5-Expressing Stem Cells in Epithelial Renewal and Cancer in the Reproductive Tract (Annie Ng, Nick Barker)....Pages 45-59 Tumor-Initiating Cells in Ovarian Cancer (Sharmila A. Bapat)....Pages 61-71 Emerging Role of CD44 Variant 6 in Driving the Metastatic Journey of Ovarian Cancer Stem Cells (Takeshi Motohara, Hidetaka Katabuchi)....Pages 73-88 Clinical Management of Primary Ovarian Insufficiency (Yoshinori Okamura)....Pages 89-99 Rescue for Primary Ovarian Insufficiency (Kyu Sup Lee)....Pages 101-112 Current Status of Ovarian Tissue Vitrification as a Fertility Preservation for the Young Cancer Patients (Nao Suzuki)....Pages 113-121 Molecular Pathogenesis of Ovarian Cancer: An Inextricable Maze (Masaki Mandai)....Pages 123-134 Clinical Management of Epithelial Ovarian Cancer (Yusuke Kobayashi, Hiroyuki Nomura, Fumio Kataoka, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki)....Pages 135-151 Molecular Targeted Therapy for Epithelial Ovarian Cancer (Hironori Tashiro, Hidetaka Katabuchi)....Pages 153-166
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