Molecular Genetics and Personalized Medicine

Description

Genetic testing has become commonplace, and clinicians are frequently able to use knowledge of an individual’s specific genetic differences to guide their course of action. Molecular Genetics and Personalized Medicine highlights developments that have been made in the field of molecular genetics and how they have been applied clinically. It will serve as a useful reference for physicians hoping to better understand the role of molecular medicine in clinical practice. In addition, it should also prove to be an invaluable resource for the basic scientist that wants to better understand how advances in the laboratory are being moved from the bench to the bedside. All chapters are written by experts in their fields and include the most up to date medical information. The authors simplify complex genetic concepts and focus on practical patient related issues. The book will be of great value to pathologists, hematologists/oncologists, clinical geneticists, high-risk obstetricians, general practitioners, and physicians in all other medical specialties who utilize genetic testing to direct therapy. Front Matter....Pages i-x Molecular Genetic Testing in the Genomic Era....Pages 1-19 Array Comparative Genomic Hybridization in Cytogenetics and Molecular Genetics....Pages 21-35 Pharmacogenomics: Tailoring Treatment Based on Genotype....Pages 37-50 Somatic Alterations and Targeted Therapy....Pages 51-101 Genome-Wide Association Studies in Disease Risk Calculation: The Role of Bioinformatics in Patient Care....Pages 103-129 Presymptomatic Genetic Testing: Shifting the Emphasis from Reaction to Prevention....Pages 131-146 Prenatal Testing: Screening, Diagnosis, and Preimplantation Genetic Diagnosis....Pages 147-162 Newborn Screening for Metabolic Disorders....Pages 163-197 The Role of Genetic Counseling in Everyday Medical Practice....Pages 199-213 Direct-to-Consumer Genetic Testing....Pages 215-236 Back Matter....Pages 237-243