Fishman's Pulmonary Diseases and Disorders, 2-Volume Set

Description

The definitive guide to the clinical and scientific aspects of pulmonary medicine―fully updated with the latest advances in the field Fishman’s Pulmonary Diseases and Disorders delivers unparalleled coverage of pulmonary medicine. With nearly 2500 illustrations, 60 videos, and 22,000 references, this peerless, two-volume resource provides a comprehensive overview of the scientific basis of lung function in health and disease. You’ll find detailed coverage of the broad array of disorders affecting the respiratory system, including obstructive and restrictive diseases, pulmonary vascular disorders, sleep-disordered breathing, lung neoplasms, respiratory infections, and respiratory failure. In addition, you’ll learn about all the latest advances, including molecular development of the lung, stem cells and respiratory disease, the genetics of pulmonary disease, the growth of personalized medicine, technical advances in lung transplantation, and much more. Notable new content in the 6th edition includes discussion of the respiratory effects of vaping, detailed consideration of the idiopathic interstitial pneumonitides, state-of the-art discussion of lung nodules, a summary of the use of immunotherapy in the treatment of lung cancer, COVID-19-related lung disease and its management, and a comprehensive discussion of noninvasive ventilation, including its use in ambulatory and ICU settings. In addition, new chapters on cystic lung disease, lung cancer screening, the lung microbiome, developmental lung disorders, nocardiosis and actinomycosis, and application of ECMO are included. Cover Title Page Copyright Page Dedication Contents Contributors Preface PART 1: Perspectives 1 Milestones in the History of Pulmonary Medicine PART 2: Scientific Basis of Lung Function in Health and Disease SECTION 1 Genetic, Cellular, and Structural Basis of Normal Lung Function 2 Functional Design of the Human Lung for Gas Exchange 3 The Respiratory Muscles 4 Molecular Regulation of Lung Development 5 Pulmonary Surfactant and Disorders of Surfactant Homeostasis 6 Mucociliary Clearance 7 The Genetic Basis of Respiratory Disorders 8 Stem Cells and Respiratory Disease: Prospects for the Future 9 Personalized Pulmonary Medicine SECTION 2 Physiological Principles of Normal Lung Function 10 Pulmonary Mechanics 11 Control of Ventilation 12 Sleep and Circadian Rhythms 13 The Pulmonary Circulation 14 Ventilation, Pulmonary Blood Flow, and Ventilation–Perfusion Relationships 15 Blood Gas Transport 16 Diffusion, Chemical Reactions, and Diffusing Capacity 17 Acid–Base Balance 18 Aging of the Respiratory System SECTION 3 Lung Immunology 19 Innate and Adaptive Immunity in the Lung 20 Macrophages and Lymphocytes in the Lung 21 Mast Cells and Eosinophils 22 Antibody-Mediated Lung Defenses and Humoral Immunodeficiency SECTION 4 Lung Injury and Repair 23 T Cell Responses in the Lung 24 Chemokines, Adipokines, and Growth Factors in the Lung 25 Redox Signaling and Oxidative Stress in Lung Diseases 26 Fibroblasts in Lung Homeostasis and Disease PART 3: Symptoms and Signs of Respiratory Disease SECTION 5 Clinical Approach to the Patient 27 Approach to the Patient with Respiratory Symptoms SECTION 6 Diagnostic Procedures 28 Modern Approach to Thoracic Imaging Diagnosis 29 Thoracic Ultrasonography 30 Physiologic and Metabolic Assessment of Pulmonary Disorders Using Conventional Imaging Techniques and Positron Emission Tomography 31 Pulmonary Function Testing 32 Principles and Application of Cardiopulmonary Exercise Testing 33 Diagnostic Bronchoscopy, Transthoracic Needle Biopsy, and Related Procedures 34 Interventional Pulmonology 35 Diagnostic Thoracic Surgical Procedures: Thoracoscopy, VATS, RATS, and Thoracotomy 36 Evaluation of Respiratory Impairment and Disability PART 4: Obstructive Lung Diseases SECTION 7 Chronic Obstructive Pulmonary Disease 37 Pathology of Chronic Obstructive Pulmonary Disease: Diagnostic Features and Differential Diagnosis 38 Chronic Obstructive Pulmonary Disease: Epidemiology, Pathophysiology, Pathogenesis 39 Chronic Obstructive Pulmonary Disease and ?1-Antitrypsin Deficiency 40 Course and Treatment of Chronic Obstructive Pulmonary Disease 41 Cigarette Smoking, Smoking Cessation, and Electronic Cigarettes 42 Rehabilitation in Chronic Obstructive Pulmonary Disease and Other Respiratory Disorders SECTION 8 Asthma 43 The Biology of Asthma 44 The Epidemiology of Asthma 45 Asthma: Clinical Presentation and Management 46 Allergic Bronchopulmonary Aspergillosis (Mycosis) and Severe Asthma with Fungal Sensitivity SECTION 9 Other Obstructive Disorders 47 Upper Airway Obstruction in Adults 48 Cystic Fibrosis 49 Bronchiolitis 50 Bullous Lung Disease 51 Bronchiectasis PART 5: Interstitial and Inflammatory Lung Diseases 52 Interstitial Lung Disease: A Clinical Overview and General Approach 53 Systemic Sarcoidosis 54 Idiopathic Pulmonary Fibrosis 55 Idiopathic Interstitial Pneumonias Other Than Idiopathic Pulmonary Fibrosis 56 Hypersensitivity Pneumonitis 57 Radiation Pneumonitis 58 Pulmonary Manifestations of the Collagen Vascular Diseases 59 Pulmonary Langerhans Cell Histiocytosis 60 Pulmonary Lymphangioleiomyomatosis 61 Diffuse Cystic Lung Diseases 62 Benign Metastasizing Leiomyoma 63 Depositional Lung Disorders: Amyloidosis, Pulmonary Calcification, and Pulmonary Ossification PART 6: Drug-Induced Lung Diseases 64 Pulmonary Toxicity Related to Systemic Treatments for Cancer 65 Drug-induced Pulmonary Disease Due to Nonchemotherapeutic Agents 66 Lung Injury Associated with Recreational Drug Use PART 7: Other Infiltrative and Airspace Disorders 67 The Lungs in Patients with Inborn Errors of Metabolism 68 Alveolar Hemorrhage Syndromes 69 Aspiration-Related Pulmonary Disorders 70 Pulmonary Alveolar Proteinosis Syndrome 71 Eosinophilic Lung Diseases 72 Pulmonary Arterial Hypertension PART 8: Disorders of the Pulmonary Circulation 73 Pulmonary Thromboembolic Disease 74 Pulmonary Vasculitis 75 Pulmonary Arteriovenous Malformations PART 9: Disorders of the Pleural Space 76 Nonmalignant Pleural Effusions 77 Malignant Pleural Effusions 78 Malignant Mesothelioma and Other Primary Pleural Tumors 79 Pneumothorax PART 10: Diseases of the Mediastinum 80 Nonneoplastic Disorders of the Mediastinum 81 Congenital Cysts of the Mediastinum: Bronchopulmonary Foregut Anomalies 82 Primary Benign and Malignant Neoplasms of the Mediastinum PART 11: Disorders of the Chest Wall, Diaphragm, and Spine 83 Nonmuscular Diseases of the Chest Wall 84 Effects of Neuromuscular Diseases on Ventilation PART 12: Occupational and Environmental Disorders SECTION 10 Occupational Disorders 85 Asbestos-Related Lung Disease 86 Chronic Beryllium Disease and Hard-Metal Lung Diseases 87 Coal Workers’ Lung Diseases and Silicosis 88 Occupational Asthma, Byssinosis, and Industrial Bronchitis SECTION 11 Environmental Disorders 89 Indoor and Outdoor Air Pollution 90 Acute and Chronic Responses to Toxic Inhalations 91 High-Altitude Physiology and Clinical Disorders 92 Diving Physiology and Dysbarism 93 Thermal Lung Injury and Acute Smoke Inhalation PART 13: Pulmonary Complications of Nonpulmonary Disorders 94 Noninfectious Pulmonary Complications of Hematopoietic Stem Cell and Solid Organ Transplantation 95 Pulmonary Complications of Sickle Cell Disease 96 Pulmonary Disorders and Pregnancy 97 Pulmonary Complications of Intra-abdominal Disease PART 14: Sleep and Sleep Disorders 98 Sleep Apnea Syndromes: Central and Obstructive 99 Sleep-related Hypoventilation Syndromes 100 Changes in the Cardiorespiratory System During Sleep 101 Differential Diagnosis and Evaluation of Sleepiness PART 15: Surgical Aspects of Pulmonary Medicine 102 Perioperative Respiratory Considerations in the Surgical Patient 103 Acute Respiratory Failure in the Surgical Patient 104 Thoracic Trauma 105 Developmental Disorders of the Lung 106 Lung Transplantation PART 16: Cancer and Other Malignancies of the Lungs 107 Genetic and Molecular Changes in Lung Cancer: Prospects for a Personalized Pharmacologic Approach to Treatment 108 Epidemiology of Lung Cancer 109 Lung Cancer Screening 110 Approach to the Patient with Pulmonary Nodules 111 The Pathology of Bronchogenic Carcinoma 112 Clinical Evaluation, Diagnosis, and Staging of Lung Cancer 113 Treatment of Non–Small-Cell Lung Cancer: Surgery 114 Treatment of Non–Small-Cell Lung Cancer: Chemotherapy and Immunotherapy 115 Treatment of Non–Small-Cell Lung Cancer: Radiation Therapy 116 Small Cell Lung Cancer: Diagnosis, Treatment, and Natural History 117 Uncommon Tumors of the Lung 118 Extrapulmonary Syndromes Associated with Lung Tumors 119 Lymphoproliferative Diseases Involving the Lung PART 17: Infectious Diseases of the Lungs SECTION 12 General Concepts 120 Pulmonary Clearance of Infectious Agents 121 The Lung Microbiome 122 Approach to Pulmonary Infection in the Immunocompetent Host 123 Approach to Pulmonary Infection in the Immunocompromised Host 124 Microbial Virulence Factors in Pulmonary Infections 125 Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia SECTION 13 Common Syndromes in Pulmonary Infectious Diseases 126 Viral Infections of the Lung and Respiratory Tract 127 Aspiration, Empyema, Lung Abscesses, and Anaerobic Infections 128 Acute Bronchitis and Community-Acquired Pneumonia 129 Nosocomial Pneumonia, Including Ventilator-associated Pneumonia SECTION 14 Major Pathogens in Pulmonary Infections 130 Tuberculosis 131 Pulmonary Diseases Due to Nontuberculous Mycobacteria 132 Aspergillus, Candida, and Other Opportunistic Pulmonary Mycoses 133 Cryptococcosis and the Endemic Mycoses: Histoplasma, Blastomyces, and Coccidioides 134 Pneumocystis Pneumonia 135 Protozoan Infections of the Thorax 136 Helminthic Diseases of the Lung 137 Nocardiosis and Actinomycosis 138 Zoonotic and Environmental Bacterial Pneumonias PART 18: Respiratory Failure 139 Respiratory Failure: An Overview SECTION 15 Lung Failure 140 Acute Respiratory Distress Syndrome: Pathogenesis 141 Acute Respiratory Distress Syndrome: Clinical Features, Management, and Outcomes SECTION 16 Respiratory Pump Failure 142 Chronic Hypercapnic Respiratory Failure: Pathogenesis and Management SECTION 17 Management and Therapeutic Interventions 143 Oxygen Therapy and Toxicity 144 Pulmonary Pharmacotherapy 145 Intubation and Upper Airway Management 146 Hemodynamic and Respiratory Monitoring in Acute Respiratory Failure 147 Principles of Mechanical Ventilation 148 Principles of Noninvasive Pressure-targeted Ventilation 149 Extracorporeal Membrane Oxygenation (ECMO) in Acute Respiratory Failure 150 Nutrition in Pulmonary Disease 151 Diagnosis and Treatment of Pain, Agitation, and Delirium in the Intensive Care Unit 152 Ethics and Palliative Care in Critical Care Units APPENDIXES Appendix A Terms and Symbols in Respiratory Physiology Appendix B Normal Values for a Healthy 20-Year Old Seated Man Index