Hallucinogens

Description

Hallucinogens......Page 1 Introduction......Page 2 Historical perspective......Page 3 Toxicity and addiction......Page 4 The chemical classes of hallucinogens......Page 5 Psychopharmacological effects of hallucinogens......Page 7 Historical relationship between serotonin and hallucinogen action......Page 8 Evidence for agonist activity at the serotonin2A receptor subtype......Page 9 Signaling through the serotonin2A receptor: agonist trafficking......Page 13 Neuroanatomical localization of serotonin2A receptors......Page 15 Functional consequences of serotonin2A receptor activation in prefrontal cortex......Page 18 Effects on cortical glutamate......Page 19 Hallucinogens increase cortical metabolism......Page 24 Dopaminergic effects of hallucinogens......Page 25 Serotonin2A receptor activation alters gene expression......Page 26 Are other receptors important to the actions of hallucinogens?......Page 27 Is the serotonin1A receptor important?......Page 28 Possible potentiating effects of interactions at other receptor subtypes......Page 30 Clinical relevance of serotonin2A receptors......Page 32 Treatment of alcoholism and substance abuse......Page 33 Clinical studies of N,N-dimethyltryptamine......Page 34 Studies of psilocybin......Page 35 Effects on cognition and perception: future tools for cognitive neuroscience......Page 36 References......Page 38