ENGLISH

Modulation of MHC Antigen Expression and Disease

By G. Eric Blair , Craig R. Pringle , D. John Maudsley

Book information

Year
1995
ISBN
9780521495783, 9780511525339, 0521499216, 0521495784, 0511525338, 9780521499217
LCC
QR184.315 .M63 1995
Open Library ID
OL1270055M
Language
english
Format
DJVU
Filesize
4 MB (3692541 bytes)
Edition
1st
Pages
457\457
Topic
Medicine Diseases
DPI
300
Orientation
no
Scanned
yes
Time added
2011-06-04 13:46:07

Description

The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.

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