Williams Hematology, 10th Edition

Description

The landmark text that has guided generations of hematologists and related practitioners updated with the latest research findings and improved format and presentation Doody's Core Titles for 2022! Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases?all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources Cover Title Page Copyright Page Contributors Preface PART I Clinical Evaluation of the Patient 1. Initial Approach to the Patient: History and Physical Examination 2. Examination of Blood and Marrow Cells 3. Consultative Hematology PART II The Organization of the Lymphohematopoietic Tissues 4. Structure of the Marrow and the Hematopoietic Microenvironment 5. The Organization and Structure of Lymphoid Tissues PART III Epochal Hematology 6. Hematology of the Fetus and Newborn 7. Hematology During Pregnancy 8. Hematology in Older Persons PART IV Molecular and Cellular Hematology 9. Genetic Principles and Molecular Biology 10. Genomics and Epigenomics 11. Cytogenetic and Genetic Abnormalities 12. Application of Big Data and Deep Learning in Hematology 13. Metabolism of Hematologic Neoplastic Cells 14. Cell Death 15. Cell-Cycle Regulation and Hematologic Disorders 16. Signal Transduction Pathways 17. Hematopoietic Stem Cells, Progenitors, and Cytokines 18. The Inflammatory Response 19. Innate Immunity 20. The Biology of Innate Lymphoid Cells and Natural Killer Cells 21. Dendritic Cells and Adaptive Immunity PART V Therapeutic Principles 22. Immune Checkpoint Inhibitors 23. Immune Cell Therapy: Chimeric Antigen Receptor T-Cell Therapy 24. Immune Cell Therapy: Dendritic Cell and Natural Killer Cell Therapy 25. Vaccine Therapy 26. Gene Therapy for Hematologic Diseases 27. Regenerative Medicine: Induced Pluripotent Stem Cells and Blood Cell Engineering 28. Pharmacology and Toxicity of Antineoplastic Drugs 29. Hematopoietic Stem Cell Transplantation 30. Therapeutic Apheresis: Indications, Efficacy, and Complications 31. Treatment of Infections in the Immunocompromised Host 32. Antithrombotic Therapy PART VI The Erythrocyte 33. Structure and Composition of the Erythrocyte 34. Erythropoiesis and Red Cell Turnover 35. Clinical Manifestations and Classification of Erythrocyte Disorders 36. Aplastic Anemia: Acquired and Inherited 37. Pure Red Cell Aplasia 38. Anemia of Chronic Disease 39. Erythropoietic Effects of Endocrine Disorders 40. The Hereditary Dyserythropoietic Anemias 41. Paroxysmal Nocturnal Hemoglobinuria 42. Folate, Cobalamin, and Megaloblastic Anemias 43. Iron Metabolism 44. Iron Deficiency and Overload 45. Anemia Resulting from Other Nutritional Deficiencies 46. Anemia Associated with Marrow Infiltration 47. Erythrocyte Membrane Disorders 48. Erythrocyte Enzyme Disorders 49. Thalassemia: A Disorder of Globin Synthesis 50. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities 51. Methemoglobinemia and Other Dyshemoglobinemias 52. Fragmentation Hemolytic Anemia 53. Erythrocyte Disorders as a Result of Toxic Agents 54. Hemolytic Anemia Resulting from Infections with Microorganisms 55. Hemolytic Anemia Resulting from Immune Injury 56. Alloimmune Hemolytic Disease of the Fetus and Newborn 57. Hypersplenism and Hyposplenism 58. Primary and Secondary Erythrocytoses/Polycythemias 59. The Porphyrias 60. Polyclonal and Hereditary Sideroblastic Anemias PART VII Neutrophils, Eosinophils, Basophils, and Mast Cells 61. Structure and Composition of Neutrophils, Eosinophils, and Basophils 62. Classification and Clinical Manifestations of Neutrophil Disorders 63. Neutropenia and Neutrophilia 64. Disorders of Neutrophil Function 65. Eosinophils and Their Disorders 66. Basophils and Mast Cells and Their Disorders PART VIII Monocytes and Macrophages 67. Structure, Receptors, and Functions of Monocytes and Macrophages 68. Production, Distribution, and Activation of Monocytes and Macrophages 69. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages 70. Monocytosis and Monocytopenia 71. Inflammatory and Malignant Histiocytosis 72. Gaucher Disease and Related Lysosomal Storage Diseases PART IX Lymphocytes and Plasma Cells 73. The Structure of Lymphocytes and Plasma Cells 74. Lymphopoiesis 75. Functions of B Lymphocytes and Plasma Cells In Immunoglobulin Production 76. Functions of T Lymphocytes: T-Cell Receptors for Antigen 77. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders 78. Lymphocytosis and Lymphocytopenia 79. Immunodeficiency Diseases 80. Hematologic Manifestations of Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome 81. Mononucleosis Syndromes PART X Malignant Myeloid Diseases 82. Classification and Clinical Manifestations of the Clonal Myeloid Disorders 83. Polycythemia Vera 84. Essential Thrombocythemia 85. Primary Myelofibrosis 86. Myelodysplastic Syndromes 87. Acute Myelogenous Leukemia 88. Chronic Myelogenous Leukemia and Related Disorders PART XI Malignant Lymphoid Diseases 89. Classification of Malignant Lymphoid Disorders 90. Acute Lymphoblastic Leukemia 91. Chronic Lymphocytic Leukemia 92. Hairy Cell Leukemia 93. Large Granular Lymphocytic Leukemia 94. General Considerations of Lymphomas: Incidence Rates, Etiology, Diagnosis, Staging, and Primary Extranodal Disease 95. Pathology of Lymphomas 96. Hodgkin Lymphoma 97. Diffuse Large B-Cell Lymphoma and Related Diseases 98. Follicular Lymphoma 99. Mantle Cell Lymphoma 100. Marginal Zone B-Cell Lymphomas 101. Burkitt Lymphoma 102. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sézary Syndrome) 103. Mature T-Cell and Natural Killer Cell Lymphomas 104. Plasma Cell Neoplasms: General Considerations 105. Essential Monoclonal Gammopathy 106. Myeloma 107. Immunoglobulin Light Chain Amyloidosis 108. Macroglobulinemia 109. Heavy-Chain Disease PART XII Hemostasis and Thrombosis 110. Megakaryopoiesis and Thrombopoiesis 111. Platelet Morphology, Biochemistry, and Function 112. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis 113. Control of Coagulation Reactions 114. Vascular Function in Hemostasis 115. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis 116. Thrombocytopenia 117. Heparin-Induced Thrombocytopenia 118. Hereditary and Reactive Thrombocytosis 119. Inherited Platelet Disorders 120. Acquired Qualitative Platelet Disorders 121. The Vascular Purpuras 122. Hemophilia A and Hemophilia B 123. Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIII 124. Hereditary Fibrinogen Abnormalities 125. VON Willebrand Disease 126. Antibody-Mediated Coagulation Factor Deficiencies 127. Disseminated Intravascular Coagulation 128. Thrombotic Microangiopathies 129. Hemolytic Uremic Syndrome 130. Hemostatic Alterations in Liver Diseases and Liver Transplantation 131. Hereditary Thrombophilia 132. The Antiphospholipid Syndrome 133. Venous Thrombosis 134. Atherothrombosis: Disease Initiation, Progression, and Treatment 135. Fibrinolysis and Thrombolysis PART XIII Transfusion Medicine 136. Erythrocyte Antigens and Antibodies 137. Human Leukocyte and Platelet Antigens 138. Blood Procurement and Red Cell Transfusion 139. Preservation and Clinical Use of Platelets 140. Using Plasma and Plasma Component Therapy