ENGLISH

Inflammasomes: Clinical and Therapeutic Implications

By Mario D. Cordero , Elísabet Alcocer-Gómez

Book information

Publisher
Springer International Publishing
Year
2018
ISBN
978-3-319-89389-1;978-3-319-89390-7
Language
english
Format
PDF
Filesize
8 MB (8300165 bytes)
Series
Experientia Supplementum 108
Edition
1st ed.
Pages
VIII, 400\404
Time added
2019-01-12 07:45:10
Biomedicine; Molecular Medicine; Medical Biochemis

Description

The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1β has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated. Front Matter ....Pages i-viii Inflammasomes in Clinical Practice: A Brief Introduction (Elísabet Alcocer-Gómez, Beatriz Castejón-Vega, Macarena López-Sánchez, Mario D. Cordero)....Pages 1-8 The Inflammasomes in Cardiovascular Disease (Gerardus P. J. van Hout, Lena Bosch)....Pages 9-40 Inflammasomes in CNS Diseases (Eduardo A. Albornoz, Trent M. Woodruff, Richard Gordon)....Pages 41-60 Lung Diseases (Saleela M. Ruwanpura, Sarah Rosli, Michelle D. Tate)....Pages 61-84 Traumatic Injury (Borna Relja, Johann-Philipp Horstmann)....Pages 85-110 Inflammasome in the Pathogenesis of Pulmonary Diseases (Fengying Xu, Zongmei Wen, Xueying Shi, Jie Fan)....Pages 111-151 Inflammasome and Oral Diseases (Pedro Bullon, Luis E. Pavillard, Rafael de la Torre-Torres)....Pages 153-176 Inflammasomes in the Kidney (Holly L. Hutton, Maliha A. Alikhan, A. Richard Kitching)....Pages 177-210 Pro-Inflammatory Actions of Red Blood Cell-Derived DAMPs (Viktória Jeney)....Pages 211-233 Role of Inflammasomes in the Development of Gastrointestinal Diseases (Mazhar A. Kanak, Yoshitaro Shindo, Pavithra SaiKumar, Bashoo Naziruddin)....Pages 235-268 Inflammasomes in Bone Diseases (Gabriel Mbalaviele, Deborah J. Veis)....Pages 269-279 Inflammasome and Cancer (Zhiyu Wang, Neng Wang, Yifeng Zheng, Shengqi Wang)....Pages 281-302 Aging and the Inflammasomes (Fabiola Marín-Aguilar, Jesús Ruiz-Cabello, Mario D. Cordero)....Pages 303-320 Genetics of Inflammasomes (Wanessa Cardoso da Silva, Edione C. Reis, Telma M. Oshiro, Alessandra Pontillo)....Pages 321-341 Inhibiting Inflammasomes with Small Molecules (Avril A. B. Robertson)....Pages 343-400

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