Recurrent Pregnancy Loss: Causes, Controversies and Treatment

Description

Major advances in genetics, immunology, and endocrinology have necessitated a new edition of this best-selling text. However, despite the advances, recurrent pregnancy loss presents a frustrating clinical problem. There is still disagreement about the number of pregnancy losses which warrant investigation and treatment and about which investigations should be performed. This third edition provides an authoritative and comprehensive update on advances in the understanding and management of this troubling phenomenon, covering both basic scientific topics such as genetics and cytokines, and profiles major advances in immunology, endocrinology, and thrombotic mechanism. Clinical research is discussed, as is assessment of results when applying an evidence-based approach or a more personalised approach, which is now becoming possible due to advances in the diagnosis of cause. There are lively debates on the role of progestogens and immunotherapy, which remain controversial. Designed for specialists working in reproductive medicine clinics and those involved with maternal-fetal care, the book is also ideal for generalists and gynecologists seeking a comprehensive view of developments in the field. Cover Half Title Series Page Title Page Copyright Page Contents Preface Contributors Part I: Basic Principles 1. The Epidemiology of Recurrent Pregnancy Loss 2. The Signaling between Embryo and Mother as a Basis for the Development of Tolerance 3. Recurrent Pregnancy Loss from Evidence-Based to Personalized Medicine Part II: Etiology 4. The Genetics of Spontaneous Abortions 5. The Endometrial Factor in Recurrent Pregnancy Loss 6. Fetal Structural Malformations and Recurrent Pregnancy Loss 7. The Endocrinology of Recurrent Pregnancy Loss 8. The Etiology of the Antiphospholipid Syndrome 9. Defects in Coagulation Factors Leading to Recurrent Pregnancy Loss 10. The Immunobiology of Recurrent Miscarriage 11. Immune Testing in Recurrent Pregnancy Loss 12. Uterine Anomalies and Recurrent Pregnancy Loss 13. The Male Factor in Recurrent Pregnancy Loss Part III: The Developing Pregnancy 14. Ultrasound Follow-Up in Early Pregnancy 15. Threatened Miscarriage and Recurrent Pregnancy Loss 16. The Role of Cerclage and Pessaries 17. What Genetic Screening Is Appropriate in Recurrent Pregnancy Loss? 18. Obstetric Outcomes after Recurrent Pregnancy Loss Part IV: Management 19. Investigation Protocol for Recurrent Pregnancy Loss 20. Debate: Should Progestogens Be Used in Recurrent Pregnancy Loss? Yes 21. Debate: Should Progestogens Be Used in Recurrent Pregnancy Loss? No 22. Human Chorionic Gonadotropin Supplementation in Recurrent Pregnancy Loss 23. Antiphospholipid Syndrome: Management of the Obstetric Patient 24. Can Recurrent Pregnancy Loss Be Prevented by Antithrombotic Agents? 25. Empirical In Vitro Fertilization for Recurrent Pregnancy Loss: Is It a Valid Concept? 26. Debate: Should PGT-A Still Be Performed in Recurrent Pregnancy Loss? Yes 27. Debate: Should PGT-A Still Be Performed in Recurrent Pregnancy Loss? No 28. Third Party Reproduction in Recurrent Pregnancy Loss Part V: Immunotherapy 29. Leucocyte Immunotherapy for Recurrent Miscarriage 30. IVIg Treatment for Recurrent Pregnancy Loss 31. The Role of Filgrastim 32. Opinion: Immunotherapy Has No Place in the Treatment of Recurrent Pregnancy Loss Index