Bone Cancer: Progression and Therapeutic Approaches

Description

The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease - both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays Copyright Page......Page 2 Foreword......Page 3 Preface......Page 4 List of Contributors......Page 5 Epidemiology and Economical Aspects of Bone Cancer......Page 10 References......Page 9 References......Page 16 References......Page 47 References......Page 52 References......Page 64 References......Page 72 References......Page 81 References......Page 101 References......Page 110 Acknowledgement......Page 118 Bone Markers of cancer(Genes and Proteins)......Page 124 References......Page 123 References......Page 137 References......Page 150 Genetic Aspects of Bone Tumors......Page 159 Benign......Page 160 Malignant......Page 161 Malignant......Page 162 Small round cell tumors of bone......Page 164 References......Page 166 References......Page 169 References......Page 179 References......Page 191 References......Page 198 References......Page 206 References......Page 220 References......Page 230 References......Page 238 Imaging of Bone Cancer......Page 247 References......Page 246 References......Page 262 References......Page 276 References......Page 288 References......Page 304 References......Page 311 References......Page 323 References......Page 336 References......Page 353 References......Page 363 References......Page 372 References......Page 394 References......Page 403 References......Page 412 References......Page 425 References......Page 433 References......Page 441 B\r......Page 450 D\r......Page 451 I\r......Page 452 N\r......Page 453 O\r......Page 454 P\r......Page 455 T\r......Page 456 Z......Page 457