ENGLISH

Molecular Biology of Long Non-coding RNAs

By Ahmad M. Khalil

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-030-17085-1;978-3-030-17086-8
Language
english
Format
PDF
Filesize
4 MB (3902710 bytes)
Edition
2nd ed.
Pages
VII, 187\189
Time added
2019-09-18 12:18:38
Biomedicine; Human Genetics; Protein Science; Syst

Description

This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them. Front Matter ....Pages i-vii Complex Regulation of X-Chromosome Inactivation in Mammals by Long Non-coding RNAs (J. Mauro Calabrese)....Pages 1-33 Chemical Modifications and Their Role in Long Non-coding RNAs (Sindy Zander, Roland Jacob, Tony Gutschner)....Pages 35-63 Long Non-coding RNAs and Nuclear Body Formation and Function (Alina Naveed, Ellen Fortini, Ruohan Li, Archa H. Fox)....Pages 65-84 New Insights into the Molecular Mechanisms of Long Non-coding RNAs in Cancer Biology (Ligia I. Torsin, Mihnea P. Dragomir, George A. Calin)....Pages 85-113 The Role of Long Non-coding RNAs in Melanoma Genesis and Progression (Piyush Joshi, Ranjan J. Perera)....Pages 115-126 Long Non-coding RNAs in the Development and Maintenance of Lymphoid Malignancies (Melanie Winkle, Agnieszka Dzikiewicz-Krawczyk, Joost Kluiver, Anke van den Berg)....Pages 127-149 Long Non-coding RNAs in Vascular Health and Disease (Viorel Simion, Stefan Haemmig, Mark W. Feinberg)....Pages 151-179 Back Matter ....Pages 181-187

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