ENGLISH

Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing

By Hamed Alborzinia (auth.)

Book information

Publisher
Springer Spektrum
Year
2015
ISBN
978-3-658-10160-2, 978-3-658-10161-9
DOI
10.1007/978-3-658-10161-9
Language
english
Format
PDF
Filesize
10 MB (10931049 bytes)
Edition
1
Pages
153\160
Time added
2015-07-18 18:00:00
Cancer Research; Pharmacology/Toxicology; Medicina

Description

Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.

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