ENGLISH

The Histamine H Receptor: A Target for New Drugs

By Rob Leurs and Henk Timmerman (Eds.)

Book information

Publisher
Elsevier, Academic Press
Year
1998
ISBN
0444829369, 9780444829368, 9780080534008
ISSN
0165-7208
LCC
QP364.7 .H56 1998
Open Library ID
OL386009M
Language
english
Format
PDF
Filesize
14 MB (14417748 bytes)
Series
Pharmacochemistry Library 30
Edition
1st
Pages
1-291\304
Topic
Chemistry
Time added
2011-06-04 13:46:07

Description

In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues.In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.

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