ENGLISH

Nanoscale Imaging of Synapses: New Concepts and Opportunities

By U. Valentin Nägerl , Antoine Triller (eds.)

Book information

Publisher
Humana Press
Year
2014
ISBN
1461491789, 9781461491781
DOI
10.1007/978-1-4614-9179-8
ISSN
0893-2336
LCC
2014931399
Language
english
Format
PDF
Filesize
8 MB (8312104 bytes)
Series
Neuromethods 84
Edition
1
Pages
231\243
Topic
Medicine Neurology
Orientation
yes
Paginated
yes
Scanned
portrait
Time added
2014-04-02 16:17:03
Neurosciences; Neurobiology

Description

Synapses underlie rapid and flexible neural communication in the brain and they hold the key to understanding higher brain functions in health and disease. Because they are very small and highly dynamic, it is very difficult to study them with traditional techniques. Fortunately, recent ground-breaking advances in optical microscopy (e.g. STED, PALM, STORM, SIM) have greatly improved our ability to image living synapses at the nanoscale, even down to the level of single molecules. The proposed volume brings together leading researchers to review these exciting new techniques and their application in neurobiological research. It will explain and discuss the basic principles behind the various superresolution modalities, how they are implemented, what their scope and limitations are etc. In addition, several key research discoveries on synapses enabled by these novel approaches will be highlighted.

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