Developmental and reproductive toxicology
Book information
Description
This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resourc e for researchers working in this vital field of study. Read more... Abstract: This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Read more... Front Matter ....Pages i-xii Metabolism and Drug–Drug Interaction in Pregnant Mother/Placenta/Fetus (Ali S. Faqi, Karsten A. Holm)....Pages 1-16 Critical Periods of Development in Teratology (Padmanahban Rengasamy)....Pages 17-42 Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Conducting Fertility, Embryo–Fetal Development, and Prenatal and Postnatal Developmental Toxicology Studies (Kevin H. Denny, Ali S. Faqi)....Pages 43-115 A Developmental and Reproductive Toxicology Program for Chemical Registration (Kamin J. Johnson, Bethany R. Hannas, Sue Marty, Carol L. Zablotny, Jessica LaRocca, Nicholas Ball et al.)....Pages 117-183 The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility (Sellappan Selvaraju, Meritxell Jodar, Stephen A. Krawetz)....Pages 185-203 Effects of Chemicals on Mammary Gland Development (Adam J. Filgo, Ali S. Faqi)....Pages 205-234 Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals (Maia L. Green, Joshua T. Gamse, Kimberly C. Brannen)....Pages 235-259 Using the Alternative Model C. elegans in Reproductive and Developmental Toxicology Studies (Daniel W. Ferreira, Yichang Chen, Patrick Allard)....Pages 261-278 High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays (Quanwen Li, Yu Yang, Erica Louden, Elizabeth E. Puscheck, Daniel A. Rappolee)....Pages 279-312 Back Matter ....Pages 313-314
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