Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization

Description

This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research directions. With more than half the world's drugs and various toxins targeting these crucial structures, the book addresses a topic of major importance in the field of medicine, particularly biosensor design, diagnostic tool development, vaccine formulation, micro/nano-array systems, and drug screening/development. Provides fundamental knowledge on biomimetic lipid membranes;Addresses some of biomimetic membrane types, preparation methods, properties and characterization techniques;Explains state-of-art technological developments that incorporate microfluidic systems, array technologies, lab-on-a-chip-tools, biosensing, and bioprinting techniques;Describes the integration of biomimetic membranes with current top-notch tools and platforms;Examines applications in medicine, pharmaceutical industry, and environmental monitoring. Front Matter ....Pages i-xxix Structural and Mechanical Characterization of Supported Model Membranes by AFM (Berta Gumí-Audenis, Marina I. Giannotti)....Pages 1-27 To Image the Orientation and Spatial Distribution of Reconstituted Na+,K+-ATPase in Model Lipid Membranes (Tripta Bhatia, Flemming Cornelius)....Pages 29-46 Asymmetric Model Membranes: Frontiers and Challenges (Michael H. L. Nguyen, Brett W. Rickeard, Mitchell DiPasquale, Drew Marquardt)....Pages 47-71 Modeling of Cell Membrane Systems (Tuğba Arzu Özal İldeniz)....Pages 73-108 Molecular Dynamics Studies of Nanoparticle Transport Through Model Lipid Membranes (Cynthia J. Jameson, Priyanka Oroskar, Bo Song, Huajun Yuan, Sohail Murad)....Pages 109-165 Investigation of Cell Interactions on Biomimetic Lipid Membranes (Abdulhalim Kılıç, Fatma Neşe Kök)....Pages 167-181 Tethered Lipid Membranes as Platforms for Biophysical Studies and Advanced Biosensors (Jakob Andersson, Wolfgang Knoll)....Pages 183-191 Biomedical Applications: Liposomes and Supported Lipid Bilayers for Diagnostics, Theranostics, Imaging, Vaccine Formulation, and Tissue Engineering (M. Özgen Öztürk Öncel, Bora Garipcan, Fatih Inci)....Pages 193-212 Lipid Bilayers and Liposomes on Microfluidics Realm: Techniques and Applications (Fatih Inci)....Pages 213-223 Biomimetic Model Membranes as Drug Screening Platform (Rumeysa Bilginer, Ahu Arslan Yildiz)....Pages 225-247 Biomimetic Membranes as an Emerging Water Filtration Technology (Reyhan Sengur-Tasdemir, Havva Esra Tutuncu, Nevin Gul-Karaguler, Esra Ates-Genceli, Ismail Koyuncu)....Pages 249-283 Applications of Lipid Membranes-based Biosensors for the Rapid Detection of Food Toxicants and Environmental Pollutants (Georgia-Paraskevi Nikoleli, Dimitrios P. Nikolelis, Christina G. Siontorou, Marianna-Thalia Nikolelis, Stephanos Karapetis)....Pages 285-297 Back Matter ....Pages 299-306