Hippocampal Microcircuits: a Computational Modeler's Resource Book

Description

The hippocampus is amongst the most widely studied of mammalian brain regions (see The Hippocampus Book, Eds. P. Andersen, R. Morris, D. Amaral, T. Bliss, J. O'Keefe. Oxford University Press, 2007) and is hypothesized to play a role in the short-term storage of declarative memories. Recent years have witnessed a dramatic accumulation of knowledge about the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus.;Intro; Introduction; Contents; Contributors; Part I Experimental Background; Connectivity of the Hippocampus; Overview; Microscopical Anatomy and Nomenclature; The Standard Connectional View; Entorhinal-Hippocampal Projections; EC Projections to DG, CA3 and CA2; EC Projections to CA1 and Sub; Synaptic Organization; Projections from CA1 and Subiculum to Entorhinal Cortex; Transverse and Laminar Organization; Longitudinal Organization; Entorhinal Associational and Commissural System; Connections of the Dentate Gyrus; Mossy Fibre Projections to Hilus and CA3 Intro Introduction Contents Contributors Part I Experimental Background Connectivity of the Hippocampus Overview Microscopical Anatomy and Nomenclature The Standard Connectional View Entorhinal-Hippocampal Projections EC Projections to DG, CA3 and CA2 EC Projections to CA1 and Sub Synaptic Organization Projections from CA1 and Subiculum to Entorhinal Cortex Transverse and Laminar Organization Longitudinal Organization Entorhinal Associational and Commissural System Connections of the Dentate Gyrus Mossy Fibre Projections to Hilus and CA3 The DG Associational and Commissural SystemConnections of CA3 The CA3 to Dentate Projections The CA3 Associational/Commissural System The CA3 to CA1 System: Schaffer Collaterals Connections of CA1 The CA1 to CA3 Projection The CA1 Associational and Commissural System The CA1 to Subiculum Projection The CA1 to Entorhinal Projection Connections of Subiculum The Subiculum to CA1 Projection The Subiculum Associational System The Subiculum to Entorhinal Projection Neurons, Numbers and Connections Experimental Techniques The Future: Open Questions and How to Address Them Resources Further ReadingMorphology of Hippocampal Neurons Overview The Data Anatomical Structure and Nomenclature Principal Cells CA1 Pyramidal Cells Positional Differences in the Anatomical, Molecular, and Functional Properties of CA1 Pyramidal Cells Along the Medio-Distal and Septotemporal Axes CA3 Pyramidal Cells CA2 Pyramidal Cells DG Granule Cells Adult-Born GCs Hilar Mossy Cells GABAergic Interneurons Morphological Classification of Interneurons Neurochemical Classification of Interneurons Interneurons of the CA1-3 Areas Perisomatic Inhibitory Interneurons Dendritic Inhibitory InterneuronsInterneuron-Specific Interneurons INs with Local and Long-Range Projecting Axons Interneurons of the DG and Hilus Perisomatic Inhibitory Interneurons Dendritic Inhibitory Interneurons Genetic Diversity of Hippocampal Interneurons Experimental Techniques Golgi Silver Staining Method Immunocytochemistry Targeted Labeling of Single Cells In Vivo Labeling of Single Cells The Future Further Reading Physiological Properties of Hippocampal Neurons The Data CA1 Pyramidal Neurons CA3 Pyramidal Neurons CA2 Pyramidal Neurons Dentate Gyrus Granule NeuronsDentate Gyrus Mossy Cells Hippocampal Interneurons Experimental Techniques The Future Further Reading Glutamatergic Neurotransmission in the Hippocampus Introduction The Perforant Pathway AMPA Receptors NMDA Receptors Metabotropic Glutamate Receptors Mossy Fibers AMPA Receptors Mossy Fiber: CA3 Pyramidal Cell Synapses Mossy Fiber: Interneuron Synapse NMDA Receptors Kainate Receptor Postsynaptic Receptors Presynaptic Receptors Metabotropic Glutamate Receptors Schaffer Collaterals AMPA Receptors NMDA Receptors Kainate Receptors