Hippocampal Microcircuits: A Computational Modeler's Resource Book

Description

This is the 2nd edition of a very well received and popular book that reflects the current state-of-the-art of the ongoing research avenues concerning the hippocampus and processing units bridging the gap between single cell activity, network activity and global brain function. It aims to provide a methodology to anyone interested in developing microcircuit level models of the hippocampus. The book is divided into two thematic areas: (I) Experimental background and (II) Computational analysis. In part I, leading experimental neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Behaviour-related ensemble activity patterns of morphologically identified neurons in anesthetized and freely moving animals provide insights on the function of the hippocampal areas. In part II, computational neuroscientists present models of the hippocampal microcircuits at various levels of detail (e.g. single cell level, network level, etc.). Synaptomics and connectomics models of hippocampal structures are initially discussed. Then, network models of memory, rhythm generation and spatial navigation are presented, followed by abstract and biophysical models of synaptic plasticity. Network models of hippocampal implicated disorders (epilepsy and schizophrenia) are then detailed and how their network topologies, connectivities and activities change in these diseases. Finally, two chapters are dedicated to describing simulator environments of single neurons and networks currently used by computational neuroscientists in developing their models and modelling tools to parametrically constrain them. This engaging volume is invaluable to experimental and computational neuroscientists, electrical engineers, physicists, mathematicians and others interested in developing microcircuit models of the hippocampus. Graduate level students and trainees in all of these fields can find this book a significant source of information. Front Matter ....Pages i-xvii Front Matter ....Pages 1-3 Connectivity of the Hippocampus (Menno P. Witter)....Pages 5-28 Morphology of Hippocampal Neurons (Imre Vida, Claudius E. Degro, Sam A. Booker)....Pages 29-90 Physiological Properties of Hippocampal Neurons (Marco Martina, Cheng-Chang Lien)....Pages 91-126 Glutamatergic Neurotransmission in the Hippocampus (Katalin Tóth)....Pages 127-157 Fast and Slow GABAergic Transmission in Hippocampal Circuits (Marlene Bartos, Jonas-Frederic Sauer, Imre Vida, Ákos Kulik)....Pages 159-200 Synaptic Plasticity at Hippocampal Synapses: Experimental Background (Jack Mellor)....Pages 201-226 Neuromodulation of Hippocampal Cells and Circuits (J. Josh Lawrence, Stuart Cobb)....Pages 227-325 Cell Type-Specific Activity During Hippocampal Network Oscillations In Vitro (Tengis Gloveli, Sam A. Booker, Nancy Kopell, Tamar Dugladze)....Pages 327-364 Recording Identified Neurons in Awake and Anesthetized Rodents (John J. Tukker)....Pages 365-409 Spatial, Temporal, and Behavioral Correlates of Hippocampal Neuronal Activity: A Primer for Computational Analysis (Howard Eichenbaum)....Pages 411-435 Front Matter ....Pages 437-440 Systematic Data Mining of Hippocampal Synaptic Properties (Keivan Moradi, Giorgio A. Ascoli)....Pages 441-471 Spatiotemporal Patterns of Granule Cell Activity Revealed by a Large-Scale, Biologically Realistic Model of the Hippocampal Dentate Gyrus (Gene J. Yu, Phillip J. Hendrickson, Dong Song, Theodore W. Berger)....Pages 473-508 A Model of Spatial Reach in LFP Recordings (Henrik Lindén, Tom Tetzlaff, Szymon Łeski, Klas H. Pettersen, Sonja Grün, Markus Diesmann et al.)....Pages 509-533 Models of Rate and Phase Coding of Place Cells in Hippocampal Microcircuits (Vassilis Cutsuridis)....Pages 535-566 A Model for Grid Firing and Theta-Nested Gamma Oscillations in Layer 2 of the Medial Entorhinal Cortex (Matt Nolan)....Pages 567-584 Computational Models of Grid Cell Firing (Daniel Bush, Christoph Schmidt-Hieber)....Pages 585-613 Modeling Synaptic Plasticity in Hippocampus: A Calcium-Based Approach (Michael Graupner, Nicolas Brunel)....Pages 615-644 Simplified Compartmental Models of CA1 Pyramidal Cells of Theta-Modulated Inhibition Effects on Spike Timing-Dependent Plasticity (Vassilis Cutsuridis)....Pages 645-667 Factors Affecting STDP in the Dendrites of CA1 Pyramidal Cells (Ausra Saudargiene, Bruce P. Graham)....Pages 669-700 Computational Examination of Synaptic Plasticity and Metaplasticity in Hippocampal Dentate Granule Neurons (Azam Shirrafiardekani, Ahmed A. Moustafa)....Pages 701-736 Genome-Wide Associations of Schizophrenia Studied with Computer Simulation (Samuel A. Neymotin, Nathan S. Kline, Mohamed A. Sherif, Jeeyune Q. Jung, Joseph J. Kabariti, William W. Lytton)....Pages 737-754 Modelling Epileptic Activity in Hippocampal CA3 (Sanjay M., Srinivasa B. Krothapalli)....Pages 755-775 A Network Model Reveals That the Experimentally Observed Switch of the Granule Cell Phenotype During Epilepsy Can Maintain the Pattern Separation Function of the Dentate Gyrus (Alexander Hanuschkin, Man Yi Yim, Jakob Wolfart)....Pages 777-803 Resources for Modeling in Computational Neuroscience (Justas Birgiolas, Sharon M. Crook, Richard C. Gerkin)....Pages 805-828 Experiment-Modelling Cycling with Populations of Multi-compartment Models: Application to Hippocampal Interneurons (Vladislav Sekulić, Frances K. Skinner)....Pages 829-859 Correction to: Modelling Epileptic Activity in Hippocampal CA3 (Sanjay M., Srinivasa B. Krothapalli)....Pages C1-C1 Back Matter ....Pages 861-879