Quantitative Models for Microscopic to Macroscopic Biological Macromolecules and Tissues

Description

This book presents cutting-edge research on the use of physical and mathematical formalisms to model and quantitatively analyze biological phenomena ranging from microscopic to macroscopic systems. The systems discussed in this compilation cover protein folding pathways, gene regulation in prostate cancer, quorum sensing in bacteria to mathematical and physical descriptions to analyze anomalous diffusion in patchy environments and the physical mechanisms that drive active motion in large sets of particles, both fundamental descriptions that can be applied to different phenomena in biology. All chapters are written by well-known experts on their respective research fields with a vast amount of scientific discussion and references in order the interested reader can pursue a further reading. Given these features, we consider Quantitative Models for Microscopic to Macroscopic Biological Macromolecules and Tissues as an excellent and up-to-date resource and reference for advanced undergraduate students, graduate students and junior researchers interested in the latest developments at the intersection of physics, mathematics, molecular biology, and computational sciences. Such research field, without hesitation, is one of the most interesting, challenging and active of this century and the next. Front Matter ....Pages i-xiii Diverse Protein-Folding Pathways and Functions of β-Hairpins and β-Sheets (Curtis Balusek, Hyea Hwang, Anthony Hazel, Karl Lundquist, Anna Pavlova, James C. Gumbart)....Pages 1-20 MicroRNAs, Gene’s Regulator in Prostate Cancer (David Alejandro de la Rosa Pérez, Carlos Omar Germán-Garrido, Raúl Aragón-Franco, Jose Gadú Campos-Saucedo, Cesar López-Camarillo, Minerva Camacho-Nuez et al.)....Pages 21-36 Subdiffusive Transport in Heterogeneous Patchy Environments (Sergei Fedotov, Helena Stage)....Pages 37-58 The Non-equilibrium Nature of Active Motion (Francisco J. Sevilla)....Pages 59-86 Homeostasis from a Time-Series Perspective: An Intuitive Interpretation of the Variability of Physiological Variables (Ruben Fossion, Jean Pierre J. Fossion, Ana Leonor Rivera, Octavio A. Lecona, Juan C. Toledo-Roy, Karla P. García-Pelagio et al.)....Pages 87-109 Looking for Biomarkers in Physiological Time Series (Ana Leonor Rivera, Bruno Estañol, Adriana Robles-Cabrera, Juan C. Toledo-Roy, Ruben Fossion, Alejandro Frank)....Pages 111-131 An Agent-Based Model to Study Selection of Pseudomonas aeruginosa Quorum Sensing by Pyocyanin: A Multidisciplinary Perspective on Bacterial Communication (Ammar Jalalimanesh, Christina Kuttler, Rodolfo García-Contreras, Judith Pérez-Velázquez)....Pages 133-147 Zinc Efflux in Trichomonas vaginalis: In Silico Identification and Expression Analysis of CDF-Like Genes (J. C. Torres-Romero, María Elizbeth Alvarez-Sánchez, K. Fernández-Martín, L. C. Alvarez-Sánchez, V. Arana-Argáez, M. Ramírez-Camacho et al.)....Pages 149-168 System Biology, Metabolomics, and Breast Cancer: Where We Are and What Are the Possible Consequences on the Clinical Setting (Alejandra Armengol-Alonso, Meztli L. Matadamas-Guzman, Osbaldo Resendis-Antonio)....Pages 169-188 Dynamical Features of a Biochemical Interaction in a Plant Root Hair Cell (Víctor F. Breña-Medina)....Pages 189-215 Back Matter ....Pages 217-226